A genome scan in 260 inflammatory bowel disease-affected relative pairs

被引：24

作者：

Barmada, MM

Brant, SR

Nicolae, DL

Achkar, JP

Panhuysen, CI

Bayless, TM

Cho, JH

Duerr, RH

机构：

[1] Univ Pittsburgh, Dept Human Genet, Grad Sch Publ Hlth, Pittsburgh, PA 15261 USA

[2] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD USA

[3] Johns Hopkins Univ, Dept Epidemiol, Bloomberg Sch Publ Hlth, Baltimore, MD USA

[4] Univ Chicago, Dept Stat, Chicago, IL 60637 USA

[5] Cleveland Clin Fdn, Dept Gastroenterol, Cleveland, OH 44195 USA

[6] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA

[7] Univ Chicago, Dept Med, Chicago, IL 60637 USA

[8] Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA USA

来源：

INFLAMMATORY BOWEL DISEASES | 2004年 / 10卷 / 01期

关键词：

chromosome mapping; colitis; ulcerative genetics; Crohn's disease genetics; genetic predisposition to disease; genotype; human; inflammatory bowel diseases genetics; linkage (genetics); major histocompatibility complex;

D O I：

10.1097/00054725-200401000-00002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We report the results of a new genome scan in 260 IBD-affected relative pairs from 139 families that we have recruited since our previous IBD genome scans were performed. The goal of our study was to determine whether we could extend the linkage evidence in any of the more than 20 regions with nominal evidence for linkage to IBD in previous individual genome scans in order to prioritize regions for further study.

引用

收藏

页码：15 / 22

页数：8

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