Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait

被引：4

作者：

Knight, J ^{[1
]}

North, BV

Sham, PC

Curtis, D

机构：

[1] Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, London WC2R 2LS, England

[2] St Bartholomews & Royal London Sch Med & Dent, Joint Acad Dept Psychol Med, London, England

来源：

BMC GENETICS | 2003年 / 4卷 / Suppl 1期

关键词：

D O I：

10.1186/1471-2156-4-S1-S74

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

This paper presents a method of performing model-free LOD-score based linkage analysis on quantitative traits. It is implemented in the QMFLINK program. The method is used to perform a genome screen on the Framingham Heart Study data. A number of markers that show some support for linkage in our study coincide substantially with those implicated in other linkage studies of hypertension. Although the new method needs further testing on additional real and simulated data sets we can already say that it is straightforward to apply and may offer a useful complementary approach to previously available methods for the linkage analysis of quantitative traits.

引用

页数：4

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