The molecular pharmacology of organic anion transporters: from DNA to FDA?

被引：59

作者：

Eraly, SA

Bush, KT

Sampogna, RV

Bhatnagar, V

Nigam, SK

机构：

[1] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Family Med, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA

[5] Vet Affairs Hosp, La Jolla, CA USA

来源：

MOLECULAR PHARMACOLOGY | 2004年 / 65卷 / 03期

关键词：

D O I：

10.1124/mol.65.3.479

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Renal organic anion secretion has been implicated in numerous clinically significant drug interactions and adverse reactions, indicating the importance of a detailed understanding of this pathway for the development of optimum therapeutics. With the cloning of multiple genes encoding organic anion transporters (OATs), the study of organic anion secretion has entered the molecular age. In this review, we focus on various aspects of the molecular biology and pharmacology of the OATs, including discussion of their structural biology, genomic organization in pairs, developmental regulation, toxicology, and pharmacogenetics. We propose functional, pathophysiological, and evolutionary hypotheses to help explain recent experimental and genomic data.

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页码：479 / 487

页数：9

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