A SacII polymorphism in the human ASCL2 (HASH2) gene region

被引：3

作者：

Miyamoto, T

Jinno, Y

Miura, K

Sengoku, K

Soejima, H

Yun, K

Yaginuma, Y

Niikawa, N

Ishikawa, M

机构：

[1] Asahikawa Med Coll, Dept Obstet & Gynecol, Asahikawa, Hokkaido 078, Japan

[2] Nagasaki Univ, Sch Med, Dept Human Genet, Nagasaki 852, Japan

[3] Nagasaki Univ, Sch Med, Dept Obstet & Gynecol, Nagasaki 852, Japan

[4] Univ Otago, Sch Med, Dept Pathol, Dunedin, New Zealand

来源：

JOURNAL OF HUMAN GENETICS | 1998年 / 43卷 / 01期

关键词：

Ascl2; 11p15.5; polymorphism; imprinting;

D O I：

10.1007/s100380050041

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The mouse achaete-scute homolog-2 gene (Ascl2 or Mash2) encodes a transcription factor playing a role in the development of the trophoblast. The Ascl2 gene is paternally imprinted in the mouse, but whether this applies to its human homolog is unknown. In the present study, we found a SacII polymorphism in the possible 3' untranslated region (UTR) of the gene. It would be very useful to determine definitively whether the gene is imprinted, as well as to analyze the allelic methylation status of the gene.

引用

页码：69 / 70

页数：2

共 4 条

[1] The human Achaete-Scute homologue 2 (ASCL2,HASH2) maps to chromosome 11p15.5, close to IGF2 and is expressed in extravillus trophoblasts [J].

Alders, M ;

Hodges, M ;

Hadjantonakis, AK ;

Postmus, J ;

vanWijk, I ;

Bliek, J ;

deMeulemeester, M ;

Westerveld, A ;

Guillemot, F ;

Oudejans, C ;

Little, P ;

Mannens, M .

HUMAN MOLECULAR GENETICS, 1997, 6 (06) :859-867

[2] GENOMIC IMPRINTING OF MASH2, A MOUSE GENE REQUIRED FOR TROPHOBLAST DEVELOPMENT [J].

GUILLEMOT, F ;

CASPARY, T ;

TILGHMAN, SM ;

COPELAND, NG ;

GILBERT, DJ ;

JENKINS, NA ;

ANDERSON, DJ ;

JOYNER, AL ;

ROSSANT, J ;

NAGY, A .

NATURE GENETICS, 1995, 9 (03) :235-242

[3] ESSENTIAL ROLE OF MASH-2 IN EXTRAEMBRYONIC DEVELOPMENT [J].

GUILLEMOT, F ;

NAGY, A ;

AUERBACH, A ;

ROSSANT, J ;

JOYNER, AL .

NATURE, 1994, 371 (6495) :333-336

[4] Genomic cloning and localization to chromosome 11p15.5 of the human achaete-scute homolog 2 (ASCL2) [J].

Miyamoto, T ;

Jinno, Y ;

Sasaki, T ;

Ikeda, Y ;

Masuzaki, H ;

Niikawa, N ;

Ishikawa, M .

CYTOGENETICS AND CELL GENETICS, 1996, 73 (04) :312-314

← 1 →