Quantitative traits associated with the Type 2 diabetes susceptibility allele in Kir6.2

被引:12
作者
Weedon, MN [1 ]
Gloyn, AL [1 ]
Frayling, TM [1 ]
Hattersley, AT [1 ]
Smith, GD [1 ]
Ben-Shlomo, Y [1 ]
机构
[1] Dept Internal Med, I-06126 Perugia, Italy
关键词
D O I
10.1007/s00125-003-1135-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1021 / 1023
页数:4
相关论文
共 9 条
[1]   Of mice and men:: KATP channels and insulin secretion [J].
Aguilar-Bryan, L ;
Bryan, J ;
Nakazaki, M .
RECENT PROGRESS IN HORMONE RESEARCH, VOL 56, 2001, 56 :47-68
[2]   A putative functional polymorphism in the IGF-I gene -: Association studies with type 2 diabetes, adult height, glucose tolerance, and fetal growth in UK populations [J].
Frayling, TM ;
Hattersley, AT ;
McCarthy, A ;
Holly, J ;
Mitchell, SMS ;
Gloyn, AL ;
Owen, K ;
Davies, D ;
Smith, GD ;
Ben-Shlomo, Y .
DIABETES, 2002, 51 (07) :2313-2316
[3]   Large-scale association studies of variants in genes encoding the pancreatic β-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes [J].
Gloyn, AL ;
Weedon, MN ;
Owen, KR ;
Turner, MJ ;
Knight, BA ;
Hitman, G ;
Walker, M ;
Levy, JC ;
Sampson, M ;
Halford, S ;
McCarthy, MI ;
Hattersley, AT ;
Frayling, TM .
DIABETES, 2003, 52 (02) :568-572
[4]   An E23K single nucleotide polymorphism in the islet ATP-sensitive potassium channel gene (Kir6.2) contributes as much to the risk of Type II diabetes in Caucasians as the PPARγ Pro12Ala variant [J].
Love-Gregory, L ;
Wasson, J ;
Lin, J ;
Skolnick, G ;
Suarez, B ;
Permutt, MA .
DIABETOLOGIA, 2003, 46 (01) :136-137
[5]   The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes [J].
Nielsen, EMD ;
Hansen, L ;
Carstensen, B ;
Echwald, SM ;
Drivsholm, T ;
Glümer, C ;
Thorsteinsson, B ;
Borch-Johnsen, K ;
Hansen, T ;
Pedersen, O .
DIABETES, 2003, 52 (02) :573-577
[6]   KIR6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic p-cell ATP-Sensitive K+ channels [J].
Schwanstecher, C ;
Meyer, U ;
Schwanstecher, M .
DIABETES, 2002, 51 (03) :875-879
[7]   Variations in insulin secretion in carriers of the E23K variant in the KIR6.2 subunit of the ATP-sensitive K+ channel in the β-cell [J].
't Hart, LM ;
van Haeften, TW ;
Dekker, JM ;
Bot, M ;
Heine, RJ ;
Maassen, JA .
DIABETES, 2002, 51 (10) :3135-3138
[8]   The prevalent Glu23Lys polymorphism in the potassium inward rectifier 6.2 (KIR6.2) gene is associated with impaired glucagon suppression in response to hyperglycemia [J].
Tschritter, O ;
Stumvoll, M ;
Machicao, F ;
Holzwarth, M ;
Weisser, M ;
Maerker, E ;
Teigeler, A ;
Häring, H ;
Fritsche, A .
DIABETES, 2002, 51 (09) :2854-2860
[9]   Morphological changes in pancreatic islets of KATP channel-deficient mice: The involvement of KATP channels in the survival of insulin cells and the maintenance of islet architecture [J].
Winarto, A ;
Miki, T ;
Seino, S ;
Iwanaga, T .
ARCHIVES OF HISTOLOGY AND CYTOLOGY, 2001, 64 (01) :59-67