Antitermite Activities of Coumarin Derivatives and Scopoletin from Protium java']javanicum Burm. f.

被引：51

作者：

Adfa, Morina ^{[1
,3
]}

Yoshimura, Tsuyoshi ^{[2
]}

Komura, Kenichi ^{[1
]}

Koketsu, Mamoru ^{[1
]}

机构：

[1] Gifu Univ, Fac Engn, Dept Mat Sci & Technol, Gifu 5011193, Japan

[2] Kyoto Univ, RISH, Kyoto 6110011, Japan

[3] Bengkulu Univ, Dept Chem, Jl Raya Kandang Limun 38371, Bengkulu, Indonesia

来源：

JOURNAL OF CHEMICAL ECOLOGY | 2010年 / 36卷 / 07期

关键词：

Protium [!text type='java']java[!/text]nicum Burm f; Coptotermes formosanus Shiraki; Scopoletin; 6-Methoxycoumarin; 6-Hydroxycoumarin; Umbelliferone; SAR; COPTOTERMES-FORMOSANUS; SUBTERRANEAN TERMITE; BIOACTIVE COMPOUNDS; NMR-SPECTROSCOPY; ESSENTIAL OILS; IDENTIFICATION; WOOD; CONSTITUENTS; FLAVONOIDS; COMPONENTS;

D O I：

10.1007/s10886-010-9807-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The antitermite (termiticidal and antifeedant) activity of Protium javanicum Burm. f. extract was investigated. The ethyl acetate fraction was active. Scopoletin (1), quercetin, and stigmasterol were isolated by bioassay-guided fractionation. Scopoletin had the highest activity among the three compounds. In order to investigate the structure-activity relationship (SAR) of the methoxy and hydroxy groups at the C-6 and C-7 positions of the coumarin skeleton, we synthesized several coumarin derivatives whose chemical structures are similar to scopoletin. Scopoletin exhibited the strongest termiticidal activity among the 10 compounds tested, followed by 6-methoxycoumarin (3), 6-hydroxycoumarin (7), and umbelliferone (8). All compounds except coumarin (9) showed antifeedant activity.

引用

页码：720 / 726

页数：7

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