Cholinergic induction of network oscillations at 40 Hz in the hippocampus in vitro

被引:672
作者
Fisahn, A [1 ]
Pike, FG [1 ]
Buhl, EH [1 ]
Paulsen, O [1 ]
机构
[1] Univ Oxford, Dept Pharmacol, MRC, Anat Neuropharmacol Unit, Oxford OX1 3TH, England
基金
英国惠康基金;
关键词
D O I
10.1038/28179
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Acetylcholine is vital for cognitive functions of the brain. Although its actions in the individual cell are known in some detail(1), its effects at the network level are poorly understood(2). The hippocampus, which receives a major cholinergic input from the medial septum/diagonal band(3), is important in memory(4,5) and exhibits network activity at 40 Hz during relevant behaviours(6). Here we show that cholinergic activation is sufficient to induce 40-Hz network oscillations(7) in the hippocampus in vitro. Oscillatory activity is generated spontaneously in the CA3 subfield and can persist for hours. During the oscillatory state, principal neurons fire action potentials that are phase-related to the extracellular oscillation, but each neuron fires in only a small proportion of the cycles. Both excitatory and inhibitory synaptic events participate during the network oscillation in a precise temporal pattern. These results indicate that subcortical cholinergic input can control hippocampal memory processing by inducing fast network oscillations.
引用
收藏
页码:186 / 189
页数:4
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