Synthesis of 3,5-diacyl-4-phenyl-1,4-dihydropyridines

被引：23

作者：

Bennasar, ML ^{[1
]}

Juan, C ^{[1
]}

Bosch, J ^{[1
]}

机构：

[1] Univ Barcelona, Fac Pharm, Organ Chem Lab, E-08028 Barcelona, Spain

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 50期

关键词：

acylation; copper and compounds; pyridinium salts; pyridines;

D O I：

10.1016/S0040-4039(98)02084-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3,5-Diacyl-4-phenyl-1,4-dihydropyridines have been synthesized via a regio- and chemoselective addition of Ph2Cu(CN)Li-2 to beta-substituted N-alkylpyridinium salts, followed by acylation of the intermediate 1,4-dihydropyridines with trichloroacetic anhydride and subsequent haloform-type reaction. A similar sequence using an N-silylpyridinium salt and PhMgBr allows the preparation of the corresponding N-unsubstituted dihydropyridines. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：9275 / 9278

页数：4

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