Epidermal stem cells have the potential to assist in healing damaged tissues

被引：14

作者：

Bickenbach, Jackie R. ^{[1
,2
]}

Stern, Matthew M. ^{[1
,2
]}

Grinnell, Katie L. ^{[1
,2
]}

Manuel, Antonio ^{[1
,2
]}

Chinnathambi, Sathivel ^{[1
,2
]}

机构：

[1] Univ Iowa, Caver Coll Med, Dept Anat & Cell Biol, Iowa City, IA 52240 USA

[2] Univ Iowa, Caver Coll Med, Dept Dermatol, Iowa City, IA USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS | 2006年 / 11卷 / 01期

关键词：

D O I：

10.1038/sj.jidsymp.5650009

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 [皮肤病与性病学];

摘要：

Homeostasis of continuously renewing tissues, such as the epidermis, is maintained by somatic undifferentiated, self-renewing stem cells, which are thought to persist throughout life. Through a series of labeling experiments, we previously showed that stem cells from mouse skin did not divide often, but they did divide at a steady rate in vivo. Using our recently redefined sorting method, we isolated epidermal stem and transit amplifying (TA) cells from mouse skin. When injected into a developing blastocyst or into damaged tissues, the stem cells, but not the TA cells, could participate in the formation of new tissues. We hypothesize that all tissues contain reserved undifferentiated stem cells that are primed to react if needed. These reserve stem cells could restore the tissue in which they reside or they could be called upon to help restore another tissue that was severely damage.

引用

页码：118 / 123

页数：6

共 55 条

[1]

Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves [J].