The SirT3 Divining Rod Points to Oxidative Stress

被引：206

作者：

Bell, Eric L. ^{[1
,2
]}

Guarente, Leonard ^{[1
,2
]}

机构：

[1] MIT, Paul F Glenn Lab, Cambridge, MA 02139 USA

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

MOLECULAR CELL | 2011年 / 42卷 / 05期

基金：

美国国家卫生研究院;

关键词：

MITOCHONDRIAL COMPLEX-III; PHOSPHATE SYNTHETASE 1; FATTY-ACID OXIDATION; CALORIE RESTRICTION; LIFE-SPAN; LYSINE ACETYLATION; SIRT3-MEDIATED DEACETYLATION; DEPENDENT DEACETYLASE; MNSOD ACTIVITY; UREA CYCLE;

D O I：

10.1016/j.molcel.2011.05.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sirtuins are NAD(+) dependent deacetylases that counter aging and diseases of aging. Sirtuin research has focused on SirT1, which deacetylates transcription factors and cofactors in the nucleus. More recent findings highlight SirT3 as a mitochondrial sirtuin that regulates metabolism and oxidative stress. This review focuses on new data linking SirT3 to management of reactive oxygen species from mitochondria, which may have profound implications for aging and late-onset diseases.

引用

页码：561 / 568

页数：8

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