Cloning, expression analysis, and chromosomal localization of HIP1R, an isolog of huntingtin interacting protein (HIP1)

被引：39

作者：

Seki, N

Muramatsu, M

Sugano, S

Suzuki, Y

Nakagawara, A

Ohhira, M

Hayashi, A

Hori, T

Saito, T

机构：

[1] Natl Inst Radiol Sci, Genome Res Grp, Inage Ku, Chiba 2638555, Japan

[2] Tokyo Med & Dent Univ, Dept Bioregulat, Inst Med Res, Tokyo 113, Japan

[3] Helix Res Inst, Chiba, Japan

[4] Univ Tokyo, Inst Med Sci, Dept Virol, Tokyo, Japan

[5] Chiba Canc Ctr, Div Biochem, Chiba, Japan

来源：

JOURNAL OF HUMAN GENETICS | 1998年 / 43卷 / 04期

关键词：

huntingtin interacting protein (HIP1); leucine zipper; chromosome; 12q24; full-length enriched cDNA library; neuroblastoma;

D O I：

10.1007/s100380050087

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Huntington disease (HD) is an inherited neurodegenerative disorder which is associated with CAG expansion in the coding region of the gene for huntingtin protein. Recently, a huntingtin interacting protein, HIP1, was isolated by the yeast two-hybrid system. Here we report the isolation of a cDNA clone for HIP1R (huntingtin interacting protein-1 related), which encodes a predicted protein product sharing a striking homology with HIP1. RT-PCR analysis showed that the messenger RNA was ubiquitously expressed in various human tissues. Based on PCR-assisted analysis of a radiation hybrid panel and fluorescence in situ hybridization, HIP1R was localized to the q24 region of chromosome 12.

引用

页码：268 / 271

页数：4

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