Bolaforms with fourteen galactose units: A proposed site-directed cohesion of cancer cells

被引：27

作者：

Menger, FM ^{[1
]}

Bian, JW ^{[1
]}

Sizova, E ^{[1
]}

Martinson, DE ^{[1
]}

Seredyuk, VA ^{[1
]}

机构：

[1] Emory Univ, Dept Chem, Atlanta, GA 30322 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 02期

关键词：

D O I：

10.1021/ol030135k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The multistep synthesis of a calixarene joined to a second calixarene via a long spacer is described. Since each calixarene bears multiple galactose-based units (known to bind strongly to rat hepatoma cells), there existed the possibility of cross-linking the cancer cells into a network. The compounds did not serve this purpose, a fact potentially correctable by adjusting or rigidifying the spacer. Formation of a,"cancer net" around a solid tumor remains a viable approach to retarding growth and/or inhibiting metastasis.

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页码：261 / 264

页数：4

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