Growth hormone and adipose tissue: Beyond the adipocyte

被引：71

作者：

Berryman, Darlene E. ^{[1
,2
]}

List, Edward O. ^{[2
]}

Sackmann-Sala, Lucila ^{[2
]}

Lubbers, Ellen ^{[2
]}

Munn, Rachel ^{[2
]}

Kopchick, John J. ^{[2
,3
]}

机构：

[1] Ohio Univ, Sch Appl Hlth Sci & Wellness, Grover Ctr E338, Coll Hlth Sci & Human Performance, Athens, OH 45701 USA

[2] Ohio Univ, Edison Biotechnol Inst, Athens, OH 45701 USA

[3] Ohio Univ, Coll Osteopath Med, Dept Biomed Sci, Athens, OH 45701 USA

来源：

GROWTH HORMONE & IGF RESEARCH | 2011年 / 21卷 / 03期

关键词：

Growth hormone; Body composition; Obesity; Aging; Adipose tissue; Gender and age differences; DIET-INDUCED OBESITY; CALORIE-RESTRICTED MICE; GH REPLACEMENT THERAPY; GENE DISRUPTED MICE; AGE-RELATED-CHANGES; BODY-COMPOSITION; TRANSGENIC MICE; INSULIN-RESISTANCE; LIFE-SPAN; FACTOR-I;

D O I：

10.1016/j.ghir.2011.03.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The last two decades have seen resurgence in research focused on adipose tissue. In part, the enhanced interest stems from an alarming increase in obesity rates worldwide. However, an understanding that this once simple tissue is significantly more intricate and interactive than previously realized has fostered additional attention. While few would argue that growth hormone (GH) radically alters fat mass, newer findings revealing the complexity of adipose tissue requires that GH's influence on this tissue be reexamined. Therefore, the objective of this review is to describe the more recent understanding of adipose tissue and to summarize our current knowledge of how GH may influence and contribute to these newer complexities of this tissue with special focus on the available data from mice with altered GH action. (C) 2011 Growth Hormone Research Society. Published by Elsevier Ltd. All rights reserved.

引用

页码：113 / 123

页数：11

共 127 条

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Dose-, IGF-I- and sex-dependent changes in lipid profile and body composition during GH replacement therapy in adult onset GH deficiency [J].