Insulin-Directed Synthesis of Fluorescent Gold Nanoclusters: Preservation of Insulin Bioactivity and Versatility in Cell Imaging

被引：377

作者：

Liu, Chien-Liang ^{[2
]}

Wu, Hung-Tsung ^{[1
]}

Hsiao, Yi-Hsuan ^{[2
]}

Lai, Chih-Wei ^{[2
]}

Shih, Chun-Wei ^{[2
]}

Peng, Yung-Kang ^{[2
]}

Tang, Kuo-Chun ^{[2
]}

Chang, Hsing-Wei ^{[2
]}

Chien, Yun-Chen ^{[4
]}

Hsiao, Jong-Kai ^{[3
]}

Cheng, Juei-Tang ^{[1
]}

Chou, Pi-Tai ^{[2
]}

机构：

[1] Chi Mei Med Ctr, Dept Med Res, Yong Kang City 73101, Tainan County, Taiwan

[2] Natl Taiwan Univ, Dept Chem, Taipei 10617, Taiwan

[3] Buddhist Tzu Chi Gen Hosp, Dept Med Imaging, Taipei Branch, Hualien, Taiwan

[4] Taipei First Girls High Sch, Taipei 10045, Taiwan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 31期

关键词：

biomaterials; fluorescence; gold; imaging agents; nanostructures; NANOPARTICLE; ENKEPHALINASE; TRANSITION; CLUSTERS; PROTEIN; SIZE;

D O I：

10.1002/anie.201100299

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Go for gold: As-prepared insulin-Au nanoclusters (NCs) show intense red fluorescence, excellent biocompatibility, and preservation of natural insulin bioactivity in lowering the blood-glucose level. Their versatility in applications is demonstrated by fluorescence imaging, X-ray computed tomography, and insulin-inhibitor interactions (see picture; IDE=insulin-degrading enzyme). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7056 / 7060

页数：5

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