Characterization of poly(L-lactic acid) microspheres loaded with holmium acetylacetonate

被引：51

作者：

Nijsen, JFW

van Steenbergern, MJ

Kooijman, H

Talsma, H

Kroon-Batenburg, LMJ

van de Weert, M

van Rijk, PP

de Witte, A

Schip, ADV

机构：

[1] Univ Med Ctr Utrecht, Dept Nucl Med, NL-3808 GA Utrecht, Netherlands

[2] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Pharmaceut, Utrecht, Netherlands

[3] Univ Utrecht, Bijvoet Ctr Biomol Res, Dept Crystal & Struct Chem, Utrecht, Netherlands

来源：

BIOMATERIALS | 2001年 / 22卷 / 22期

关键词：

holmium; PLLA; acetylacetonate; MDSC; microspheres; radio therapy;

D O I：

10.1016/S0142-9612(01)00055-2

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Holmium-loaded PLLA microspheres are useful systems in radioembolization therapy of liver metastases because of their low density, biodegradability and favourable radiation characteristics. Neutron activated Ho-loaded microspheres showed a surprisingly low release of the relatively small holmium complex. In this paper factors responsible for this behaviour are investigated, in particular by the use of differential scanning calorimetry, scanning electron microscopy, infrared spectroscopy and X-ray diffraction. The holmium complex is soluble in PLLA up to 8% in films and 17% in microspheres. Interactions between carbonyl groups of PLLA, and the Ho-ion in the HoAcAc complex, explain very satisfactorily the high stability of holmium-loaded microspheres. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3073 / 3081

页数：9

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