Correlation between omental TNF-α protein and plasma PAI-1 in obesity subjects

被引:12
作者
Cao, Yan Li [1 ]
Wang, Yu Xia [2 ]
Wang, Di Fei [1 ]
Meng, Xin [1 ]
Zhang, Jin [1 ]
机构
[1] China Med Univ, Affiliated Hosp 1, Dept Endocrinol, Shenyang 110001, Liaoning, Peoples R China
[2] China Med Univ, Affiliated Hosp 4, Dept Endocrinol, Shenyang 110032, Liaoning, Peoples R China
关键词
tumor necrosis factor-alpha; obesity; plasminogen activator inhibitor 1; omentum; vascular diseases;
D O I
10.1016/j.ijcard.2007.05.033
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: The role of TNF-alpha in contributing to obesity-associated cardiovascular and metabolic risk has gained much attention. Materials and methods: Paired biopsies of omental and subcutaneous fat were collected from 16 lean subjects and 32 central obesity subjects. The expression of TNF-alpha in omental and subcutaneous fat was quantified by western blotting method, and correlations with plasma PAI-1, homeostasis model assessment insulin resistance (HOMA-IR), and lipid were investigated. Results: In obese female, TNF-alpha expression was higher in the omental than in the subcutaneous fat tissue. There was no significant difference in the levels of TNF-alpha between subcutaneous and visceral fat in obese male. Significant positive correlations were found between omental TNF-alpha protein and plasma PAI-1 levels in obesity. In obese female subjects, omental TNF-alpha protein levels showed a close association with most of the parameters studied: fasting glucose (r=0.541, P<0.05); fasting insulin (r=0.599, P<0.01); HOMA-IR (r=0.546, P<0.05); triglycerides (r=0.469, P<0.05); HDL-cholesterol (r=-0.759, P<0.01). In obese male population, correlations between omental TNF-alpha protein levels and fasting glucose (r=0.762, P<0.01); fasting insulin (r=0.622, P<0.05); triglycerides (r=0.650, P<0.05); HDL-cholesterol (r=-0.880, P<0.01) were found. Conclusion: Omental TNF-alpha may play a key role in contributing to cardiovascular risk in central obesity subjects. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:399 / 405
页数:7
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