The antioxidant properties of serum albumin

被引：896

作者：

Roche, Mariolaine ^{[1
]}

Rondeau, Philippe ^{[1
]}

Singh, Nihar Ranjan ^{[1
]}

Tarnus, Evelyne ^{[1
]}

Bourdon, Emmanuel ^{[1
]}

机构：

[1] Univ Reunion, LBGM, St Denis De La Reunion, France

来源：

FEBS LETTERS | 2008年 / 582卷 / 13期

关键词：

serum albumin; antioxidant; oxidative stress; oxidation;

D O I：

10.1016/j.febslet.2008.04.057

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Free radicals are a normal component of cellular oxygen metabolism in mammals. However, free radical-associated damage is an important factor in many pathological processes. Glycation and oxidative damage cause protein modifications, frequently observed in numerous diseases. Albumin represents a very abundant and important circulating antioxidant. This review brings together recent insights on albumin antioxidant properties. First, it focuses on the different activities of albumin concerning protein antioxidation. In particular, we describe the role of albumin in ligand binding and free radical-trapping activities. In addition, physiological and pathological situations that modify the antioxidant properties of albumin are reported. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1783 / 1787

页数：5

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