Recent advances in urocanic acid photochemistry, photobiology and photoimmunology

被引：121

作者：

Gibbs, Neil K. ^{[1
]}

Tye, Joanne ^{[1
]}

Norval, Mary ^{[2
]}

机构：

[1] Univ Manchester, Sch Med, Manchester M13 9PT, Lancs, England

[2] Univ Edinburgh, Sch Med, Edinburgh, Midlothian, Scotland

来源：

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES | 2008年 / 7卷 / 06期

关键词：

D O I：

10.1039/b717398a

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Urocanic acid ( UCA), produced in the upper layers of mammalian skin, is a major absorber of ultraviolet radiation ( UVR). Originally thought to be a 'natural sunscreen', studies conducted a quarter of a century ago proposed that UCA may be a chromophore for the immunosuppression that follows exposure to UVR. With its intriguing photochemistry, its role in immunosuppression and skin cancer development, and skin barrier function, UCA continues to be the subject of intense research effort. This review summarises the photochemical, photobiological and photoimmunological findings regarding UCA, published since 1998.

引用

页码：655 / 667

页数：13

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