Role of Apaf-1, a key regulator of apoptosis, in melanoma progression and chemoresistance

被引：46

作者：

Campioni, M

Santini, D

Tonini, G

Murace, R

Dragonetti, E

Spugnini, EP

Baldi, A

机构：

[1] Univ Naples 2, Dept Biochem & Biophys F Cedrangolo, Sect Pathol, Naples, Italy

[2] Campus Biomed Univ, Sect Oncol, Rome, Italy

[3] IML, Aeronaut Mil, Rome, Italy

[4] Rome Amer Hosp, Rome, Italy

[5] Regina Elena Inst Canc Res, Ctr Expt Res, SAFU Dept, Rome, Italy

来源：

EXPERIMENTAL DERMATOLOGY | 2005年 / 14卷 / 11期

关键词：

Apaf-1; apoptosis; chemoresistance; melanoma progression;

D O I：

10.1111/j.1600-0625.2005.00360.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Apoptosis protease-activating factor-1 (Apaf-1) is a key regulator of the mitochondrial apoptotic pathway, being the central element of the multimeric apoptosome formed by procaspase 9, cytochrome c, and Apaf-1 itself. In this review, the principal aspects about Apaf-1 gene structure and function, and its role in the apoptotic machinery, are described. Moreover, the most recent findings about the involvement of this molecule in melanoma progression and chemoresistance, as well as the clinico-pathological relevance of these findings in the treatment of this deadly disease, are reported.

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收藏

页码：811 / 818

页数：8

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