Remarkable attachment of lactoferrin to Streptococcus pyogenes during acute pharyngotonsillitis

被引:9
作者
Stenfors, LE [1 ]
Bye, HM
Vorland, LH
机构
[1] Univ Tromso, Fac Med, Dept Otolaryngol, NO-9037 Tromso, Norway
[2] Univ Tromso, Dept Med Microbiol, NO-9037 Tromso, Norway
关键词
beta-haemolytic Streptococci; inflammation; mucosal defence; mucosal immunity; palatine tonsillitis;
D O I
10.1080/000164801316878962
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
The purpose of this study was to establish whether lactoferrin (hLf) attached to Streptococcus pyogenes, one causative agent of acute pharyngotonsillitis (AT), during the course of the disease. Bacterial samples were obtained from the tonsillar surfaces of 7 patients (6 females, 1 male; median age 26 years; range 16-50 years) suffering from AT who were culture-positive for S. pyogenes and from 5 healthy adult controls who were culture-negative for this pathogen. Using gold-labelled antiserum against S. pyogenes and hLf, this pathogen and other bacteria on the tonsillar surfaces coated with hLf could be identified by tracing the gold particles in a transmission electron microscope. In healthy adults, 8% (median value; range 6-12%) of the surface tonsillar bacteria were coated with hLf In AT patients, 59% (median value; range 42-67%) of S. pyogenes were coated with hLf, in contrast to 9% (median value; range 0-26%) of all other bacteria (P < 0.01). This study hints that hLf might participate in recovery from AT in several ways, e.g. by binding to the S. pyogenes pathogens, in addition to its well-known virtue of iron-binding capacity.
引用
收藏
页码:637 / 642
页数:6
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