Toward understanding and exploiting tumor heterogeneity

被引：591

作者：

Alizadeh, Ash A. ^{[1
,2
,3
]}

Aranda, Victoria ^{[4
]}

Bardelli, Alberto ^{[5
,6
]}

Blanpain, Cedric ^{[7
]}

Bock, Christoph ^{[8
,9
]}

Borowski, Christine ^{[4
]}

Caldas, Carlos ^{[10
]}

Califano, Andrea ^{[11
,12
,13
]}

Doherty, Michael ^{[14
]}

Elsner, Markus ^{[15
]}

Esteller, Manel ^{[16
]}

Fitzgerald, Rebecca ^{[17
]}

Korbel, Jan O. ^{[18
]}

Lichter, Peter ^{[19
]}

Mason, Christopher E. ^{[20
]}

Navin, Nicholas ^{[21
,22
]}

Pe'er, Dana ^{[11
,23
]}

Polyak, Kornelia ^{[24
]}

Roberts, Charles W. M. ^{[25
]}

Siu, Lillian ^{[26
]}

Snyder, Alexandra ^{[27
]}

Stower, Hannah

Swanton, Charles ^{[28
,29
,30
]}

Verhaak, Roel G. W. ^{[22
,31
]}

Zenklusen, Jean C. ^{[32
]}

Zuber, Johannes ^{[33
]}

Zucman-Rossi, Jessica ^{[34
]}

机构：

[1] Stanford Univ, Div Oncol, Dept Med, Sch Med, Stanford, CA 94305 USA

[2] Stanford Univ, Div Hematol, Dept Med, Sch Med, Stanford, CA 94305 USA

[3] Stanford Univ, Inst Canc, Dept Med, Sch Med, Stanford, CA 94305 USA

[4] Nat Med, New York, NY 10021 USA

[5] Univ Turin, Dept Oncol, Turin, Italy

[6] IRCCS, Candiolo Canc Inst, FPO, Turin, Italy

[7] ULB, Brussels, Belgium

[8] Austrian Acad Sci, CeMM Res Ctr Mol Med, A-1010 Vienna, Austria

[9] Med Univ Vienna, Dept Lab Med, Vienna, Austria

[10] Univ Cambridge, Dept Oncol, Cambridge, England

[11] Columbia Univ, Dept Syst Biol, New York, NY USA

[12] Columbia Univ, Dept Biochem & Mol Biophys, New York, NY USA

[13] Columbia Univ, Dept Biomed Informat, New York, NY USA

[14] Genentech Inc, San Francisco, CA USA

[15] Nat Biotechnol, New York, NY USA

[16] Bellvitge Biomed Res Inst, Canc Epigenet & Biol Program, Barcelona, Catalonia, Spain

[17] Univ Cambridge, Hutchison MRC Res Ctr, MRC Canc Unit, Cambridge, England

[18] European Mol Biol Lab, Genome Biol Unit, D-69012 Heidelberg, Germany

[19] DKFZ, German Canc Res Ctr, Heidelberg, Germany

[20] Weill Cornell Med Coll, New York, NY USA

[21] Univ Texas MD Anderson Canc Ctr, Dept Genet, Houston, TX 77030 USA

[22] Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA

[23] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

[24] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[25] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA

[26] Princess Margaret Canc Ctr, Toronto, ON, Canada

[27] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA

[28] UCL, Inst Canc, London, England

[29] Univ Coll London Hosp NHS Fdn Trust, London, England

[30] Francis Crick Inst, London, England

[31] Univ Texas MD Anderson Canc Ctr, Dept Genom Med, Houston, TX 77030 USA

[32] NCI, Canc Genome Atlas Ctr Canc Gen, Bethesda, MD 20892 USA

[33] Vienna Bioctr VBC, Res Inst Mol Pathol IMP, Vienna, Austria

[34] IUH, Inserm, UMR Genom Fonct Tumeurs Solides 1162, Paris, France

来源：

NATURE MEDICINE | 2015年 / 21卷 / 08期

关键词：

INTRATUMOR HETEROGENEITY; CELLS; RNA; RESISTANCE; EVOLUTION; PATIENT; PREDICT; GENOME; DNA;

D O I：

10.1038/nm.3915

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The extent of tumor heterogeneity is an emerging theme that researchers are only beginning to understand. How genetic and epigenetic heterogeneity affects tumor evolution and clinical progression is unknown. The precise nature of the environmental factors that influence this heterogeneity is also yet to be characterized. Nature Medicine, Nature Biotechnology and the Volkswagen Foundation organized a meeting focused on identifying the obstacles that need to be overcome to advance translational research in and tumor heterogeneity. Once these key questions were established, the attendees devised potential solutions. Their ideas are presented here.

引用

页码：846 / 853

页数：8

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