Patients With Autoimmune Hepatitis Who Have Antimitochondrial Antibodies Need Long-term Follow-up to Detect Late Development of Primary Biliary Cirrhosis

被引：30

作者：

Dinani, Amreen M. ^{[4
]}

Fischer, Sandra E. ^{[3
]}

Mosko, Jeff ^{[4
]}

Guindi, Maha ^{[2
,3
]}

Hirschfield, Gideon M. ^{[1
,4
]}

机构：

[1] Univ Birmingham, Liver Res Ctr, Inst Biomed Res, Birmingham B15 2TT, W Midlands, England

[2] Cedars Sinai Med Ctr, Dept Pathol, Los Angeles, CA 90048 USA

[3] Univ Toronto, Dept Pathol, Toronto, ON, Canada

[4] Univ Toronto, Dept Med, Toronto, ON, Canada

来源：

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY | 2012年 / 10卷 / 06期

关键词：

Autoimmunity; Clinical Care; Disease Progression; Diagnosis; OVERLAP SYNDROME; LIVER-DISEASE; FEATURES;

D O I：

10.1016/j.cgh.2012.02.010

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Patients with autoiummune hepatitis (AIH) who have antibodies against mitochondrial proteins (AMA positive) are believed to have an autoimmune syndrome that should be managed as AIH. Of patients with AMA-positive AIH, we report on 3 individuals to demonstrate how autoimmune liver disease can progress over time. Specific features of primary blliary cirrhosis (PBC) overlapped in time in these patients. Our observations indicate the importance of careful follow up of patients with AMA-positive AIH; health care professionals that treat such patients should therefore be aware of longitudinal clinical changes that might indicate development of PBC in this setting.

引用

页码：682 / 684

页数：3

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