Microanalysis of a selective potent anti-Helicobacter pylori compound in a Brazilian medicinal plant, Myroxylon peruiferum and the activity of analogues

被引：52

作者：

Ohsaki, A

Takashima, J

Chiba, N

Kawamura, M

机构：

[1] Tokyo Med & Dent Univ, Inst Med & Dent Engn, Div Med Chem, Chiyoda Ku, Tokyo, Japan

[2] Mitsubishi Chem Corp, Yokohama Res Ctr, Aoba Ku, Yokohama, Kanagawa 2278502, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(99)00141-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A selective potent anti Helicobacter pylori isoflavone was isolated from a Brazilian Medicinal Plant, Myroxylon peruiferum. The isolation bioassay-guided and the characterization of an active anti-H. pylori constituent was performed using the methanol extract of plant of minute amount. The active compound was identified as cabreuvin (1), an isoflavone derivative. The structure-activity relationships of several related compounds were also investigated. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1109 / 1112

页数：4

共 17 条

[1] SYNTHESIS AND STUDY OF ISOFLAVAN-4-OLS [J].