Hypoxia and the unfolded protein response

被引：28

作者：

Koumenis, Constantinos ^{[1
]}

Bi, Meixia

Ye, Jiangbin

Feldman, Douglas

Koong, Albert C.

机构：

[1] Univ Penn, Sch Med, Dept Radiat Oncol, Philadelphia, PA 19104 USA

[2] Stanford Univ, Sch Med, Dept Radiat Oncol, Stanford, CA 94305 USA

来源：

OXYGEN BIOLOGY AND HYPOXIA | 2007年 / 435卷

关键词：

D O I：

10.1016/S0076-6879(07)35014-3

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumor hypoxia refers to the development of regions within solid tumors in which the oxygen concentration is lower (0-3%) compared to that in most normal tissues (4-9%) (Vaupel and Hockel, 2000). Considerable experimental and clinical evidence exists supporting the notion that hypoxia fundamentally alters the physiology of the tumor towards a more aggressive phenotype (Hockel and Vaupel, 2001). Therefore, delineating the mechanisms by which hypoxia affects tumor physiology at the cellular and molecular levels will be crucial for a better understanding of tumor development and metastasis and for designing better antitumor modalities.

引用

页码：275 / +

页数：22

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