Activity of oral agents against pediatric isolates of Streptococcus pneumoniae

被引:3
作者
Black, J
Moland, ES
Chartrand, SA
Thomson, KS
机构
[1] Creighton Univ, Sch Med, Dept Med Microbiol & Immunol, Ctr Res Anti Infect & Biotechnol, Omaha, NE 68178 USA
[2] Creighton Univ, Sch Med, Dept Pediat Infect Dis, Omaha, NE 68178 USA
关键词
D O I
10.1016/S0732-8893(01)00209-7
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
An in vitro study of the activity of 10 oral agents against 153 pediatric isolates of Streptococcus pneumoniae identified moxifloxacin and levofloxacin as the most active agents regardless of penicillin or macrolide susceptibility. Moxifloxacin inhibited all strains at 0.25 mug/ml and was 8- to 16-fold more potent than levofloxacin. (C) 2001 Elsevier Science inc. All rights reserved.
引用
收藏
页码:195 / 197
页数:3
相关论文
共 11 条
[1]   Fluoroquinolones as treatment for patients with lower respiratory tract infections caused by Streptococcus pneumoniae [J].
Amyes, SGB ;
Thomson, CJ .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1998, 42 (03) :398-399
[2]   Tentative minimum inhibitory concentration and zone diameter breakpoints for moxifloxacin using BSAC criteria [J].
Andrews, JM ;
Ashby, JP ;
Jevons, GM ;
Wise, R .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1999, 44 (06) :819-822
[3]   ANTIMICROBIAL RESISTANCE IN STREPTOCOCCUS-PNEUMONIAE - AN OVERVIEW [J].
APPELBAUM, PC .
CLINICAL INFECTIOUS DISEASES, 1992, 15 (01) :77-83
[4]  
*BAY CORP PHARM DI, 1999, AV MOX HYDR TABL
[5]  
Campbell GD, 1998, CLIN INFECT DIS, V26, P1188, DOI 10.1086/520286
[6]   Antipneumococcal activities of gemifloxacin compared to those of nine other agents [J].
Davies, TA ;
Kelly, LM ;
Pankuch, GA ;
Credito, KL ;
Jacobs, MR ;
Appelbaum, PC .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (02) :304-310
[7]  
FRIEDLAND IR, 1994, NEW ENGL J MED, V331, P377, DOI 10.1056/NEJM199408113310607
[8]   IN-VITRO ACTIVITY OF THE FLUOROQUINOLONE TROVAFLOXACIN AGAINST PENICILLIN-SUSCEPTIBLE AND PENICILLIN-RESISTANT STREPTOCOCCUS-PNEUMONIAE [J].
KLUGMAN, K ;
WASAS, A .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1995, 36 (05) :873-874
[9]   PNEUMOCOCCAL RESISTANCE TO ANTIBIOTICS [J].
KLUGMAN, KP .
CLINICAL MICROBIOLOGY REVIEWS, 1990, 3 (02) :171-196
[10]  
*NAT COMM CLIN LAB, 2000, 7100S10 NCCLS