Long-term outcome of vagus nerve stimulation therapy in patients with refractory epilepsy

被引：28

作者：

Abubakr, Abuhuziefa ^{[1
]}

Wambacq, Ilse ^{[1
]}

机构：

[1] Seton Hall Univ Grad Med Educ, New Jersy Neurosci Inst, JFK Hosp, Edison, NJ 08818 USA

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2008年 / 15卷 / 02期

关键词：

VNS; refractory epilepsy; responder; weight loss;

D O I：

10.1016/j.jocn.2007.07.083

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We retrospectively assessed the long-term efficacy of vagus nerve stimulation (VNS) therapy in 31 patients with refractory partial and generalized seizures who were not candidates for resective epilepsy surgery. Following implantation of VNS there was significant improvement in seizure frequency at 6 months. Sixteen patients continued to have sustained response to VNS therapy 4 years later. Adverse effects of VNS therapy were transient and tolerable. The majority of the patients did not gain body weight and some of them had significant weight loss. Therefore VNS is safe and effective therapy and has a long-term sustained effect in refractory epilepsy. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：127 / 129

页数：3

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