Functional genomics: The worm scores a knockout

被引：19

作者：

Kim, SK ^{[1
]}

机构：

[1] Stanford Univ, Dept Dev Biol, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Genet, Stanford, CA 94305 USA

来源：

CURRENT BIOLOGY | 2001年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0960-9822(01)00035-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Following the completion of the genome sequence of Caenorhabditis elegans, four independent studies have now assessed the functions of more than a third of the worm's genes by analysing the phenotypes caused when each of a large set of genes is inactivated by RNA interference.

引用

页码：R85 / R87

页数：3

共 10 条

[1] The genome sequence of Drosophila melanogaster [J].

Adams, MD ;

Celniker, SE ;

Holt, RA ;

Evans, CA ;

Gocayne, JD ;

Amanatides, PG ;

Scherer, SE ;

Li, PW ;

Hoskins, RA ;

Galle, RF ;

George, RA ;

Lewis, SE ;

Richards, S ;

Ashburner, M ;

Henderson, SN ;

Sutton, GG ;

Wortman, JR ;

Yandell, MD ;

Zhang, Q ;

Chen, LX ;

Brandon, RC ;

Rogers, YHC ;

Blazej, RG ;

Champe, M ;

Pfeiffer, BD ;

Wan, KH ;

Doyle, C ;

Baxter, EG ;

Helt, G ;

Nelson, CR ;

Miklos, GLG ;

Abril, JF ;

Agbayani, A ;

An, HJ ;

Andrews-Pfannkoch, C ;

Baldwin, D ;

Ballew, RM ;

Basu, A ;

Baxendale, J ;

Bayraktaroglu, L ;

Beasley, EM ;

Beeson, KY ;

Benos, PV ;

Berman, BP ;

Bhandari, D ;

Bolshakov, S ;

Borkova, D ;

Botchan, MR ;

Bouck, J ;

Brokstein, P .

SCIENCE, 2000, 287 (5461) :2185-2195

[2] Genome sequence of the nematode C-elegans:: A platform for investigating biology [J].

不详 .

SCIENCE, 1998, 282 (5396) :2012-2018

[3] Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans [J].

Fire, A ;

Xu, SQ ;

Montgomery, MK ;

Kostas, SA ;

Driver, SE ;

Mello, CC .

NATURE, 1998, 391 (6669) :806-811

[4] Functional genomic analysis of C-elegans chromosome I by systematic RNA interference [J].

Fraser, AG ;

Kamath, RS ;

Zipperlen, P ;

Martinez-Campos, M ;

Sohrmann, M ;

Ahringer, J .

NATURE, 2000, 408 (6810) :325-330

[5] Functional genomic analysis of cell division in C-elegans using RNAi of genes on chromosome III [J].

Gönczy, P ;

Echeverri, C ;

Oegema, K ;

Coulson, A ;

Jones, SJM ;

Copley, RR ;

Duperon, J ;

Oegema, J ;

Brehm, M ;

Cassin, E ;

Hannak, E ;

Kirkham, M ;

Pichler, S ;

Flohrs, K ;

Goessen, A ;

Leidel, S ;

Alleaume, AM ;

Martin, C ;

Özlü, N ;

Bork, P ;

Hyman, AA .

NATURE, 2000, 408 (6810) :331-336

[6] Genomic analysis of gene expression in C-elegans [J].

Hill, AA ;

Hunter, CP ;

Tsung, BT ;

Tucker-Kellogg, G ;

Brown, EL .

SCIENCE, 2000, 290 (5492) :809-812

[7]

JIANG M, 2001, IN PRESS P NATL ACAD

[8] RNAi analysis of genes expressed in the ovary of Caenorhabditis elegans [J].

Piano, F ;

Schetter, AJ ;

Mangone, M ;

Stein, L ;

Kemphues, KJ .

CURRENT BIOLOGY, 2000, 10 (24) :1619-1622

[9] A global profile of germline gene expression in C-elegans [J].

Reinke, V ;

Smith, HE ;

Nance, J ;

Wang, J ;

Van Doren, C ;

Begley, R ;

Jones, SJM ;

Davis, EB ;

Scherer, S ;

Ward, S ;

Kim, SK .

MOLECULAR CELL, 2000, 6 (03) :605-616

[10] Protein interaction mapping in C-elegans using proteins involved in vulval development [J].

Walhout, AJM ;

Sordella, R ;

Lu, XW ;

Hartley, JL ;

Temple, GF ;

Brasch, MA ;

Thierry-Mieg, N ;

Vidal, M .

SCIENCE, 2000, 287 (5450) :116-122

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