A Common HLA-DPA1 Variant is a Major Determinant of Hepatitis B Virus Clearance in Han Chinese

被引：59

作者：

An, Ping ^{[1
]}

Winkler, Cheryl ^{[1
]}

Guan, Li ^{[2
]}

O'Brien, Stephen J.

Zeng, Zheng ^{[3
]}

机构：

[1] NCI, Basic Res Lab, Frederick, MD 21702 USA

[2] NCI, Lab Genom Divers, SAIC Frederick, Frederick, MD 21702 USA

[3] Peking Univ, Dept Infect Dis, Hosp 1, Beijing 100871, Peoples R China

来源：

JOURNAL OF INFECTIOUS DISEASES | 2011年 / 203卷 / 07期

基金：

美国国家卫生研究院;

关键词：

HEPATOCELLULAR-CARCINOMA; HBSAG SEROCLEARANCE; CARRIERS; ASSOCIATION; INFECTION;

D O I：

10.1093/infdis/jiq154

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

A recent genome-wide study showed that the single nucleotide polymorphisms (SNPs) in the HLA-DP region were associated with chronic hepatitis B virus (HBV) infection in Japanese and Thai persons. We tested the effects of HLA-DP SNPs for all major HBV outcomes in Han Chinese (n = 1742): HBV resistance, clearance, chronic infection, cirrhosis, and hepatocellular carcinoma. HLA - DPA1 rs3077 T was strongly associated with decreased risk of chronic HBV infection (odds ratio, .62; P = .001), consistent with the previous report. We showed for the first time to our knowledge that it is a predictor for HBV clearance (odds ratio, 2.41; P < .001). However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma.

引用

页码：943 / 947

页数：5

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