Consequences of total and subtotal myeloperoxidase deficiency: Risk or benefit?

被引：209

作者：

Kutter, D

Devaquet, P

Vanderstocken, G

Paulus, JM

Marchal, V

Gothot, A

机构：

[1] Labs Reunis Kutter Lieners Hastert, L-6101 Junglinster, Luxembourg

[2] Hop Ville Esch sur Alzette, Esch Sur Alzette, Luxembourg

[3] Hop Princesse Marie Astrid, Differdange, Luxembourg

[4] CHU Liege Sart Tilman, Liege, Belgium

来源：

ACTA HAEMATOLOGICA | 2000年 / 104卷 / 01期

关键词：

cancer; cardiovascular atheroma; infection; inflammation; myeloperoxidase deficiency; myocardial infarction;

D O I：

10.1159/000041062

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A group of 100 totally or subtotally myeloperoxidase (MPO)-deficient individuals was compared to a reference population of 118 probands selected at random. Data for a protective effect of the deficiency against cardiovascular damage are presented. On the other hand, a significantly higher occurrence of severe infections and chronic inflammatory processes was noted among the deficient patients. An increased incidence of cancer among the MPO-deficient individuals was not demonstrated. Copyright (C) 2000 S. Karger AG, Basel.

引用

页码：10 / 15

页数：6

共 23 条

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CECH P, 1979, BLOOD, V53, P403

[2] POLYMORPHONUCLEAR LEUKOCYTE MYELOPEROXIDASE DEFICIENCY IN A PATIENT WITH MYELOMONOCYTIC LEUKEMIA [J].