Distinguishing acute from chronic and resolved hepatitis C virus (HCV) infections by measurement of Anti-HCV immunoglobulin g avidity index

被引：33

作者：

Klimashevskaya, S.

Obriadina, A.

Ulanova, T.

Bochkova, G.

Burkov, A.

Araujo, A.

Stramer, Susan L.

Tobler, Leslie H.

Busch, Michael P.

Fields, Howard A. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30333 USA

[2] RPC Diagnost Syst, Nizhnii Novgorod, Russia

[3] Amer Red Cross, Sci Support Off, Gaithersburg, MD USA

[4] Blood Syst Res Inst, San Francisco, CA USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2007年 / 45卷 / 10期

关键词：

D O I：

10.1128/JCM.01012-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

An assay to measure avidity index (AI) was developed to diagnose incident hepatitis C virus (HCV) infections. The assay demonstrated an AI value statistically significantly lower in primary HCV infections than in chronic infections. When the assay was applied to past resolved infections, the difference in AI values was not as significant as the difference between incident and chronic infections. Lower AI values obtained in past resolved infections may be directly related to lower levels of immunoglobulin G anti-HCV in past resolved infections than in either new infections or chronic infections.

引用

页码：3400 / 3403

页数：4

共 18 条

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[Anonymous], 1998, MMWR Recomm Rep, V47, P1

[2]

SIGNIFICANCE OF IGM ANTIBODY TO HEPATITIS-C VIRUS IN PATIENTS WITH CHRONIC HEPATITIS-C [J].