First stereoselective synthesis of a pro-pro E-alkene dipeptide isostere

被引：13

作者：

Bandur, NG ^{[1
]}

Harms, K ^{[1
]}

Koert, U ^{[1
]}

机构：

[1] Univ Marburg, Fachbereich Chem, D-35032 Marburg, Germany

来源：

SYNLETT | 2005年 / 05期

关键词：

proline; E-alkene; dipeptide isostere; Felkin-Anh selective alkenylation; Ireland-Claisen rearrangement;

D O I：

10.1055/s-2005-863731

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereoselective synthesis of a proline-proline E-alkene isostere is described. Starting from N-BOC-L-proline the new stereocenter is generated by diastereoselective alkenylation and subsequent Ireland-Claisen rearrangement. The relative configuration of the double bond and the new generated stereocenter were determined by X-ray crystallography.

引用

页码：773 / 776

页数：4

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