Syntheses of 4,5-diaryl-1,2,3-thiadiazoles

被引：6

作者：

Karimi, L ^{[1
]}

Navidpour, L ^{[1
]}

Amini, M ^{[1
]}

Shafiee, A ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Fac Pharm, Dept Chem, Tehran, Iran

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2005年 / 180卷 / 07期

关键词：

1,2,3-thiadiazole; 4,5-diaryl-1,2,3-thiadiazole; sulfonamide;

D O I：

10.1080/104265090884283

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Reaction of thionyl chloride with semicarbazones of 1-(4-methylsulfonylphenyl)-2-(4-substituted pheny)lethanone gave 1-(4-methylsulfonylphenyl)-5-(4-substituted) pheny-1,2,3-thiadiazoles 5. Compounds 5-phenyl-4-(substitutedphenyl)-1,2,3-thiadiazoles 14 were similarly prepared. Chlorosulfonation of the latter followed by ammonia gave the desired compounds 5-(4-aminosulfonylphenyl)-4-(substituted) phenyl-1,2,3-thiadiazoles 6.

引用

页码：1593 / 1600

页数：8

共 13 条

[1] Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line
Arico, S
Pattingre, S
Bauvy, C
Gane, P
Barbat, A
Codogno, P
Ogier-Denis, E
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (31) : 27613 - 27621
[2] Cyclooxygenase-2 (COX-2), aromatase and breast cancer: a possible role for COX-2 inhibitors in breast cancer chemoprevention
Davies, G
Martin, LA
Sacks, N
Dowsett, M
[J]. ANNALS OF ONCOLOGY, 2002, 13 (05) : 669 - 678
[3] ELOY R, 1959, B SOC CHIM BELG, V68, P423
[4] Synthesis and biological evaluation of 2,3-diarylthiophenes as selective Cox-2 inhibitors .2. Replacing the heterocycle
Gauthier, JY
Leblanc, Y
Black, WC
Chan, CC
Cromlish, WA
Gordon, R
Kennedey, BP
Lau, CK
Leger, S
Wang, ZY
Ethier, D
Guay, J
Mancini, J
Riendeau, D
Tagari, P
Vickers, P
Wong, E
Xu, LJ
Prasit, P
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (01) : 87 - 92
[5] Hawkey C, 2000, ARTHRITIS RHEUM-US, V43, P370, DOI 10.1002/1529-0131(200002)43:2<370::AID-ANR17>3.0.CO
[6] 2-D
[7] Inhibition of cyclooxygenase-2 suppresses angiogenesis and the growth of prostate cancer in vivo
Liu, XH
Kirschenbaum, A
Yao, S
Lee, R
Holland, JF
Levine, AC
[J]. JOURNAL OF UROLOGY, 2000, 164 (03) : 820 - 825
[8] Cyclooxygenase and Alzheimer's disease: implications for preventive initiatives to slow the progression of clinical dementia
Pasinetti, GM
[J]. ARCHIVES OF GERONTOLOGY AND GERIATRICS, 2001, 33 (01) : 13 - 28
[9] Cyclooxygenase-2 inhibitors suppress the growth of gastric cancer xenografts via induction of apoptosis in nude mice
Sawaoka, H
Kawano, S
Tsuji, S
Tsujii, M
Gunawan, ES
Takei, Y
Nagano, K
Hori, M
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1998, 274 (06): : G1061 - G1067
[10] 1,2,3-SELENADIAZOLYL-1,3,4-OXADIAZOLE, "1,2,3-THIADIAZOLYL-1,3,4-OXADIAZOLE AND 5-(1,2,3-THIADIAZOLYL)-S-TRIAZOLO[3,4-B]-1,3,4-THIADIAZOLES
SHAFIEE, A
LALEZARI, I
MIRRASHED, M
NERCESIAN, D
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1977, 14 (04) : 567 - 571

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