SNP/RD Typing of Mycobacterium tuberculosis Beijing Strains Reveals Local and Worldwide Disseminated Clonal Complexes

被引：23

作者：

Schurch, Anita C. ^{[1
,2
]}

Kremer, Kristin ^{[1
]}

Hendriks, Amber C. A. ^{[1
]}

Freyee, Benthe ^{[1
]}

McEvoy, Christopher R. E. ^{[3
,4
]}

van Crevel, Reinout ^{[5
]}

Boeree, Martin J. ^{[6
]}

van Helden, Paul ^{[3
]}

Warren, Robin M. ^{[3
]}

Siezen, Roland J. ^{[2
]}

van Soolingen, Dick ^{[1
,6
]}

机构：

[1] Natl Inst Publ Hlth & Environm RIVM, TB Reference Lab, Ctr Infect Dis Control, Bilthoven, Netherlands

[2] Radboud Univ Nijmegen Med Ctr NCMLS, Ctr Mol & Biomol Informat, Nijmegen, Netherlands

[3] Univ Stellenbosch, Dept Sci & Technol, Natl Res Fdn Ctr Excellence Biomed TB Res, Med Res Council Ctr Mol & Cellular Biol, Cape Town, South Africa

[4] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia

[5] Radboud Univ Nijmegen Med Ctr, Dept Med, Nijmegen, Netherlands

[6] Radboud Univ Nijmegen Med Ctr Univ Lung Ctr Dekke, Dept Pulm Dis, Nijmegen, Netherlands

来源：

PLOS ONE | 2011年 / 6卷 / 12期

关键词：

GENOMIC DELETIONS; NUCLEOTIDE POLYMORPHISMS; DISCRIMINATORY POWER; POPULATION-STRUCTURE; DIVERSITY; EVOLUTION; GENOTYPE; PHYLOGEOGRAPHY; LINEAGE; FAMILY;

D O I：

10.1371/journal.pone.0028365

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Beijing strain is one of the most successful genotypes of Mycobacterium tuberculosis worldwide and appears to be highly homogenous according to existing genotyping methods. To type Beijing strains reliably we developed a robust typing scheme using single nucleotide polymorphisms (SNPs) and regions of difference (RDs) derived from whole-genome sequencing data of eight Beijing strains. SNP/RD typing of 259 M. tuberculosis isolates originating from 45 countries worldwide discriminated 27 clonal complexes within the Beijing genotype family. A total of 16 Beijing clonal complexes contained more than one isolate of known origin, of which two clonal complexes were strongly associated with South African origin. The remaining 14 clonal complexes encompassed isolates from different countries. Even highly resolved clonal complexes comprised isolates from distinct geographical sites. Our results suggest that Beijing strains spread globally on multiple occasions and that the tuberculosis epidemic caused by the Beijing genotype is at least partially driven by modern migration patterns. The SNPs and RDs presented in this study will facilitate future molecular epidemiological and phylogenetic studies on Beijing strains.

引用

页数：9

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