共 58 条
Regulation of endosome fusion
被引:50
作者:

Mills, IG
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Physiol Lab, Liverpool L69 3BX, Merseyside, England Univ Liverpool, Physiol Lab, Liverpool L69 3BX, Merseyside, England

Jones, AT
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Physiol Lab, Liverpool L69 3BX, Merseyside, England Univ Liverpool, Physiol Lab, Liverpool L69 3BX, Merseyside, England

Clague, MJ
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liverpool, Physiol Lab, Liverpool L69 3BX, Merseyside, England Univ Liverpool, Physiol Lab, Liverpool L69 3BX, Merseyside, England
机构:
[1] Univ Liverpool, Physiol Lab, Liverpool L69 3BX, Merseyside, England
基金:
英国惠康基金;
关键词:
endosome fusion;
rab5;
early endosomal autoantigen 1;
phosphatidylinositol;
3-kinase;
D O I:
10.1080/096876899294788
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Homotypic fusion between early endosomes can be reconstituted in vitro. By using wortmannin and LY294002, inhibitors of phosphatidylinositol (PI) 3-kinase, a requirement for this activity has been established in order for fusion to proceed efficiently. It has been shown that PI 3-kinase activity is required downstream of rab5 activation, although a large excess of activated rab5 can overcome wortmannin inhibition. A series of experiments have also been performed which indicate a role for early endosomal autoantigen 1 (EEA1) in determining fusion efficiency, EEA1 dissociates from membranes following wortmannin treatment. It is proposed that the requirement of endosome fusion for PI 3-kinase activity is to promote the association of EEA1 with endosomes.
引用
收藏
页码:73 / 79
页数:7
相关论文
共 58 条
- [1] Seven novel mammalian SNARE proteins localize to distinct membrane compartments[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (17) : 10317 - 10324Advani, RJ论文数: 0 引用数: 0 h-index: 0机构: Stanford Univ, Dept Cellular & Mol Physiol, Howard Hughes Med Inst, Stanford, CA 94305 USA Stanford Univ, Dept Cellular & Mol Physiol, Howard Hughes Med Inst, Stanford, CA 94305 USABae, HR论文数: 0 引用数: 0 h-index: 0机构: Stanford Univ, Dept Cellular & Mol Physiol, Howard Hughes Med Inst, Stanford, CA 94305 USA Stanford Univ, Dept Cellular & Mol Physiol, Howard Hughes Med Inst, Stanford, CA 94305 USABock, JB论文数: 0 引用数: 0 h-index: 0机构: Stanford Univ, Dept Cellular & Mol Physiol, Howard Hughes Med Inst, Stanford, CA 94305 USA Stanford Univ, Dept Cellular & Mol Physiol, Howard Hughes Med Inst, Stanford, CA 94305 USAChao, DS论文数: 0 引用数: 0 h-index: 0机构: Stanford Univ, Dept Cellular & Mol Physiol, Howard Hughes Med Inst, Stanford, CA 94305 USA Stanford Univ, Dept Cellular & Mol Physiol, Howard Hughes Med Inst, Stanford, CA 94305 USADoung, YC论文数: 0 引用数: 0 h-index: 0机构: Stanford Univ, Dept Cellular & Mol Physiol, Howard Hughes Med Inst, Stanford, CA 94305 USA Stanford Univ, Dept Cellular & Mol Physiol, Howard Hughes Med Inst, Stanford, CA 94305 USAPrekeris, R论文数: 0 引用数: 0 h-index: 0机构: Stanford Univ, Dept Cellular & Mol Physiol, Howard Hughes Med Inst, Stanford, CA 94305 USA Stanford Univ, Dept Cellular & Mol Physiol, Howard Hughes Med Inst, Stanford, CA 94305 USAYoo, JS论文数: 0 引用数: 0 h-index: 0机构: Stanford Univ, Dept Cellular & Mol Physiol, Howard Hughes Med Inst, Stanford, CA 94305 USA Stanford Univ, Dept Cellular & Mol Physiol, Howard Hughes Med Inst, Stanford, CA 94305 USAScheller, RH论文数: 0 引用数: 0 h-index: 0机构: Stanford Univ, Dept Cellular & Mol Physiol, Howard Hughes Med Inst, Stanford, CA 94305 USA Stanford Univ, Dept Cellular & Mol Physiol, Howard Hughes Med Inst, Stanford, CA 94305 USA
- [2] WORTMANNIN IS A POTENT PHOSPHATIDYLINOSITOL 3-KINASE INHIBITOR - THE ROLE OF PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE IN NEUTROPHIL RESPONSES[J]. BIOCHEMICAL JOURNAL, 1993, 296 : 297 - 301ARCARO, A论文数: 0 引用数: 0 h-index: 0机构: UNIV FRIBOURG,INST BIOCHEM,RUE MUSEE 5,CH-1700 FRIBOURG,SWITZERLAND UNIV FRIBOURG,INST BIOCHEM,RUE MUSEE 5,CH-1700 FRIBOURG,SWITZERLANDWYMANN, MP论文数: 0 引用数: 0 h-index: 0机构: UNIV FRIBOURG,INST BIOCHEM,RUE MUSEE 5,CH-1700 FRIBOURG,SWITZERLAND UNIV FRIBOURG,INST BIOCHEM,RUE MUSEE 5,CH-1700 FRIBOURG,SWITZERLAND
- [3] ISOLATION OF YEAST MUTANTS DEFECTIVE IN PROTEIN TARGETING TO THE VACUOLE[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (23) : 9075 - 9079BANKAITIS, VA论文数: 0 引用数: 0 h-index: 0JOHNSON, LM论文数: 0 引用数: 0 h-index: 0EMR, SD论文数: 0 引用数: 0 h-index: 0
- [4] Characterization of Rab5:Q79L-stimulated endosome fusion[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1996, 326 (01) : 64 - 72Barbieri, MA论文数: 0 引用数: 0 h-index: 0机构: WASHINGTON UNIV, SCH MED, DEPT CELL BIOL & PHYSIOL, ST LOUIS, MO 63110 USALi, GP论文数: 0 引用数: 0 h-index: 0机构: WASHINGTON UNIV, SCH MED, DEPT CELL BIOL & PHYSIOL, ST LOUIS, MO 63110 USAMayorga, LS论文数: 0 引用数: 0 h-index: 0机构: WASHINGTON UNIV, SCH MED, DEPT CELL BIOL & PHYSIOL, ST LOUIS, MO 63110 USAStahl, PD论文数: 0 引用数: 0 h-index: 0机构: WASHINGTON UNIV, SCH MED, DEPT CELL BIOL & PHYSIOL, ST LOUIS, MO 63110 USA
- [5] ROLE FOR PHOSPHATIDYLINOSITOL 3-KINASE IN THE SORTING AND TRANSPORT OF NEWLY SYNTHESIZED LYSOSOMAL-ENZYMES IN MAMMALIAN-CELLS[J]. JOURNAL OF CELL BIOLOGY, 1995, 130 (04) : 781 - 796BROWN, WJ论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF SAN DIEGO, HOWARD HUGHES MED INST, DIV CELLULAR & MOLEC MED, LA JOLLA, CA 92093 USADEWALD, DB论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF SAN DIEGO, HOWARD HUGHES MED INST, DIV CELLULAR & MOLEC MED, LA JOLLA, CA 92093 USAEMR, SD论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF SAN DIEGO, HOWARD HUGHES MED INST, DIV CELLULAR & MOLEC MED, LA JOLLA, CA 92093 USAPLUTNER, H论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF SAN DIEGO, HOWARD HUGHES MED INST, DIV CELLULAR & MOLEC MED, LA JOLLA, CA 92093 USABALCH, WE论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF SAN DIEGO, HOWARD HUGHES MED INST, DIV CELLULAR & MOLEC MED, LA JOLLA, CA 92093 USA
- [6] Initial docking of ER-derived vesicles requires Uso1p and Ypt1p but is independent of SNARE proteins[J]. EMBO JOURNAL, 1998, 17 (08) : 2156 - 2165Cao, XC论文数: 0 引用数: 0 h-index: 0机构: Dartmouth Med Sch, Dept Biochem, Hanover, NH 03755 USA Dartmouth Med Sch, Dept Biochem, Hanover, NH 03755 USABallew, N论文数: 0 引用数: 0 h-index: 0机构: Dartmouth Med Sch, Dept Biochem, Hanover, NH 03755 USA Dartmouth Med Sch, Dept Biochem, Hanover, NH 03755 USABarlowe, C论文数: 0 引用数: 0 h-index: 0机构: Dartmouth Med Sch, Dept Biochem, Hanover, NH 03755 USA Dartmouth Med Sch, Dept Biochem, Hanover, NH 03755 USA
- [7] PHOSPHATIDYLINOSITOL 3-KINASE ACTIVATION IS REQUIRED FOR INSULIN STIMULATION OF PP70 S6 KINASE, DNA-SYNTHESIS, AND GLUCOSE-TRANSPORTER TRANSLOCATION[J]. MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (07) : 4902 - 4911CHEATHAM, B论文数: 0 引用数: 0 h-index: 0机构: HARVARD UNIV, BRIGHAM & WOMENS HOSP,SCH MED,JOSLIN DIABET CTR, DEPT MED,DIV RES, BOSTON, MA 02215 USAVLAHOS, CJ论文数: 0 引用数: 0 h-index: 0机构: HARVARD UNIV, BRIGHAM & WOMENS HOSP,SCH MED,JOSLIN DIABET CTR, DEPT MED,DIV RES, BOSTON, MA 02215 USACHEATHAM, L论文数: 0 引用数: 0 h-index: 0机构: HARVARD UNIV, BRIGHAM & WOMENS HOSP,SCH MED,JOSLIN DIABET CTR, DEPT MED,DIV RES, BOSTON, MA 02215 USAWANG, L论文数: 0 引用数: 0 h-index: 0机构: HARVARD UNIV, BRIGHAM & WOMENS HOSP,SCH MED,JOSLIN DIABET CTR, DEPT MED,DIV RES, BOSTON, MA 02215 USABLENIS, J论文数: 0 引用数: 0 h-index: 0机构: HARVARD UNIV, BRIGHAM & WOMENS HOSP,SCH MED,JOSLIN DIABET CTR, DEPT MED,DIV RES, BOSTON, MA 02215 USAKAHN, CR论文数: 0 引用数: 0 h-index: 0机构: HARVARD UNIV, BRIGHAM & WOMENS HOSP,SCH MED,JOSLIN DIABET CTR, DEPT MED,DIV RES, BOSTON, MA 02215 USA
- [8] WORTMANNIN CAUSES MISTARGETING OF PROCATHEPSIN-D - THE INVOLVEMENT OF A PHOSPHATIDYLINOSITOL 3-KINASE IN VESICULAR TRANSPORT TO LYSOSOMES[J]. JOURNAL OF CELL BIOLOGY, 1995, 130 (04) : 797 - 805DAVIDSON, HW论文数: 0 引用数: 0 h-index: 0机构: Department of Clinical Biochemistry, University of Cambridge, Addenbrookes Hospital
- [9] VESICLE FUSION FOLLOWING RECEPTOR-MEDIATED ENDOCYTOSIS REQUIRES A PROTEIN ACTIVE IN GOLGI TRANSPORT[J]. NATURE, 1989, 339 (6223) : 398 - 400DIAZ, R论文数: 0 引用数: 0 h-index: 0机构: PRINCETON UNIV,LEWIS THOMAS LAB,DEPT BIOL,PRINCETON,NJ 08544 PRINCETON UNIV,LEWIS THOMAS LAB,DEPT BIOL,PRINCETON,NJ 08544MAYORGA, LS论文数: 0 引用数: 0 h-index: 0机构: PRINCETON UNIV,LEWIS THOMAS LAB,DEPT BIOL,PRINCETON,NJ 08544 PRINCETON UNIV,LEWIS THOMAS LAB,DEPT BIOL,PRINCETON,NJ 08544WEIDMAN, PJ论文数: 0 引用数: 0 h-index: 0机构: PRINCETON UNIV,LEWIS THOMAS LAB,DEPT BIOL,PRINCETON,NJ 08544 PRINCETON UNIV,LEWIS THOMAS LAB,DEPT BIOL,PRINCETON,NJ 08544ROTHMAN, JE论文数: 0 引用数: 0 h-index: 0机构: PRINCETON UNIV,LEWIS THOMAS LAB,DEPT BIOL,PRINCETON,NJ 08544 PRINCETON UNIV,LEWIS THOMAS LAB,DEPT BIOL,PRINCETON,NJ 08544STAHL, PD论文数: 0 引用数: 0 h-index: 0机构: PRINCETON UNIV,LEWIS THOMAS LAB,DEPT BIOL,PRINCETON,NJ 08544 PRINCETON UNIV,LEWIS THOMAS LAB,DEPT BIOL,PRINCETON,NJ 08544
- [10] Inhibition of calcium-independent mannose 6-phosphate receptor incorporation into trans-Golgi network-derived clathrin-coated vesicles by Wortmannin[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (39) : 24170 - 24175Gaffet, P论文数: 0 引用数: 0 h-index: 0机构: UNIV LIVERPOOL,PHYSIOL LAB,LIVERPOOL L69 3BX,MERSEYSIDE,ENGLAND UNIV LIVERPOOL,PHYSIOL LAB,LIVERPOOL L69 3BX,MERSEYSIDE,ENGLANDJones, AT论文数: 0 引用数: 0 h-index: 0机构: UNIV LIVERPOOL,PHYSIOL LAB,LIVERPOOL L69 3BX,MERSEYSIDE,ENGLAND UNIV LIVERPOOL,PHYSIOL LAB,LIVERPOOL L69 3BX,MERSEYSIDE,ENGLANDClague, MJ论文数: 0 引用数: 0 h-index: 0机构: UNIV LIVERPOOL,PHYSIOL LAB,LIVERPOOL L69 3BX,MERSEYSIDE,ENGLAND UNIV LIVERPOOL,PHYSIOL LAB,LIVERPOOL L69 3BX,MERSEYSIDE,ENGLAND