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Immunohistochemical detection of the calcitonin receptor-like receptor protein in the microvasculature of rat endothelium

被引：16
作者：
Hagner, S
Haberberger, R
Hay, DL
Facer, P
Reiners, K
Voigt, K
McGregor, GP
机构：
[1] Univ Marburg, Inst Physiol, D-35037 Marburg, Germany
[2] Univ Giessen, Inst Anat & Cell Biol, Giessen, Germany
[3] Univ London Imperial Coll Sci Technol & Med, Peripheral Neuropathy Unit, London W12 0NN, England
[4] Aston Univ, Sch Life Sci, Birmingham B4 7ET, W Midlands, England
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2003年 / 481卷 / 2-3期
关键词：
calcitonin receptor-like receptor; CRL receptor; vascular endothelium; rat; immunoreactivity; GENE-RELATED PEPTIDE; ACTIVITY-MODIFYING PROTEINS; MESSENGER-RNA EXPRESSION; ADRENOMEDULLIN BINDING; IDENTIFICATION; AMYLIN; SITES; RAMPS; CELLS; LUNG;
D O I：
10.1016/j.ejphar.2003.09.030
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Calcitonin-gene-related peptide and adrenomedullin have similar and potent vascular effects, which appear to be mediated by the G protein-coupled calcitonin receptor-like (CRL) receptor. Using immunohistochemical and Western blot analyses, we have obtained novel evidence that CRL receptor is expressed in the rat vascular endothelium using an antibody to rat CRL receptor that we have raised and fully characterised. These results are an important basis for further studies aimed at determining the so far ill-defined functional significance of the extensive distribution of CRL receptor in the vascular endothelium. (C) 2003 Elsevier B.V. All rights reserved.
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页码：147 / 151
页数：5
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