Bioactive flavonoids from Kaempferia parviflora

被引：184

作者：

Yenjai, C ^{[1
]}

Prasanphen, K

Daodee, S

Wongpanich, V

Kittakoop, P

机构：

[1] Khon Kaen Univ, Fac Sci, Khon Kaen 40002, Thailand

[2] Khon Kaen Univ, Fac Pharmaceut Sci, Khon Kaen 40002, Thailand

[3] NSTDA, Natl Ctr Genet Engn & Biotechnol, Pathum Thani 20120, Thailand

来源：

FITOTERAPIA | 2004年 / 75卷 / 01期

关键词：

Kaempferia parviflora; flavonoids; antiplasmodial; antifungal; antimycobacterial; cytotoxicity;

D O I：

10.1016/j.fitote.2003.08.017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nine flavonoids (1-9) have been isolated from Kaempferia parviflora. Among these, 5,7,4'-trimethoxyflavone (8) and 5,7,3',4'-tetramethoxyflavone (9) exhibited antiplasmodial activity against Plasmodium falciparum, with IC50 values of 3.70 and 4.06 mug/ml, respectively. 3,5,7,4'-Tetramethoxyflavone (7) and compound 8 possessed antifungal activity against Candida albicans with respective IC50 values of 39.71 and 17.63 mug/ml, and also showed mild antimycobacterial activity with the minimum inhibitory concentrations (MIC) of 200 and 50 mug/ml, respectively. However, none of the isolated compounds demonstrated cytotoxicity against KB, BC and NCI-H187 cell lines. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：89 / 92

页数：4

共 8 条

[1] Microplate Alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium [J].