Asymmetric total synthesis of attenol A and B

被引：20

作者：

Enders, D ^{[1
]}

Lenzen, A ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen Klinikum, Inst Organ Chem, D-52074 Aachen, Germany

来源：

SYNLETT | 2003年 / 14期

关键词：

asymmetric dihydroxylation; dithianes; natural products; SAMP-hydrazone methodology; total synthesis;

D O I：

10.1055/s-2003-42071

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric total synthesis of attenol A (1) and B (2), which possess challenging structures and an interesting biological activity, was accomplished in a convergent and highly stereoselective manner (de, ee greater than or equal to 96%) with good overall yield. The short total synthesis is based on asymmetric alkylations of SAMP-hydrazones as well as a Sharpless asymmetric dihydroxylation as key steps.

引用

页码：2185 / 2187

页数：3

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