Long-term efficacy of single-dose combinations of albendazole, ivermectin and diethylcarbamazine for the treatment of bancroftian filariasis

被引:66
作者
Ismail, MM
Jayakody, RL
Weil, GJ
Fernando, D
De Silva, MSG
De Silva, GAC
Balasooriya, WK
机构
[1] Univ Colombo, Dept Parasitol, Fac Med, Colombo 8, Sri Lanka
[2] Washington Univ, Sch Med, St Louis, MO 63110 USA
[3] Natl Hosp Sri Lanka, Colombo 8, Sri Lanka
关键词
filariasis; Wuchereria bancrofti; chemotherapy; drug combinations; albendazole; ivermectin; diethylcarbamazine; Sri Lanka;
D O I
10.1016/S0035-9203(01)90257-3
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
In a 'blinded' trial (in Sri Lanka, 1996-98) of 47 male asymptomatic microfilaraemic subjects with Wuchereria bancrofti infection, the safety, tolerability and filaricidal efficacy of 3 single-dose combination regimens were compared: albendazole 400 mg with ivermectin 200 mug/kg, albendazole 400 mg with diethylcarbamazine citrate (DEC) 6 mg/kg or albendazole 600 mg with ivermectin 400 mug/kg. Treated subjects were followed-up for 24 months. This represents the first long-term study using combinations of albendazole with DEC or ivermectin in the above doses against bancroftian filariasis. All subjects had pretreatment microfilaria (mf) counts over 100/mL. All 3 treatments significantly reduced mf counts, with the albendazole-DEC-treated group showing the lowest mf levels at 18 and 24 months post-treatment. Filarial antigen tests suggested that all 3 treatments had significant activity against adult If: bancrofti; albendazole-DEC combination had the greatest activity according to this test, with antigen levels decreasing to 30.5% of pre-treatment antigen levels, 24 months after therapy. All 3 treatments were clinically safe and well tolerated. These results suggest that a single dose of albendazole 400 mg together with DEC 6 mg/kg is a safe and effective combination for suppression of microfilaraemia of bancroftian filariasis that could be considered for use in filariasis control programmes based on mass treatment of endemic populations.
引用
收藏
页码:332 / 335
页数:4
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