Synthesis of barettin

被引：36

作者：

Johnson, AL

Bergman, J

Sjögren, M

Bohlin, L

机构：

[1] Karolinska Inst, Novum, Dept Biosci, CNT,Unit Organ Chem, SE-14157 Huddinge, Sweden

[2] Sodertorn Univ Coll, SE-14104 Huddinge, Sweden

[3] Uppsala Univ, Biomed Ctr, Dept Med Chem, Div Pharmacognosy, SE-75123 Uppsala, Sweden

来源：

TETRAHEDRON | 2004年 / 60卷 / 04期

关键词：

Geodia barretti; barettin; N-boc protection of arginine; HWE-reaction;

D O I：

10.1016/j.tet.2003.11.031

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The indole alkaloid barettin (with bromine in 6-position), isolated from the marine sponge Geodia Barretti, has been synthesised via a Horner-Wadsworth-Emmons type reaction from 6-bromoindole-3-carboxaldehyde to introduce the dehydro-functionality. Subsequent deprotection and cyclisation afforded the natural product in Z-conformation. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：961 / 965

页数：5

共 13 条

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