Nano ceria catalyzed Ullmann type coupling reactions

被引：29

作者：

Agawane, Sandeep M. ^{[1
]}

Nagarkar, Jayashree M. ^{[1
]}

机构：

[1] Inst Chem Technol, Dept Chem, Bombay 400019, Maharashtra, India

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 41期

关键词：

Nano ceria; Synthesis and characterization; Ullmann type coupling; Copper and ligand free; Heterogeneous catalysis; ARYL IODIDES; C-N; O-ARYLATION; EFFICIENT; LIGAND; COPPER; VERSATILE; HALIDES; PHENOLS; THIOLS;

D O I：

10.1016/j.tetlet.2011.07.117

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ullmann type intermolecular coupling of aryl halide with hetero-aromatic compounds, such as phenols, amines, and thiophenols are key reactions for the formation of carbon-heteroatom bond in organic synthesis. We report a robust and novel method that provides an efficient and economic route for the synthesis of O, N, and S-arylation via Ullman coupling by using nano cerium oxide (ceria, CeO2). CeO2 is a cheaper catalyst compared to related copper based catalysts. This method provides a wide range of substrate applicability in the case of phenols and amines. Less reactive chlorobenzene substituted with strong electron withdrawing groups such as 4-nitrochlorobenzene and 4-cyanochlorobenzene favor the reaction. This protocol avoids the use of ligand and gives arylated product in satisfactory yields. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：5220 / 5223

页数：4

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