Immunobiology of the TAM receptors

被引：659

作者：

Lemke, Greg ^{[1
]}

Rothlin, Carla V. ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Mol Neurobiol Lab, La Jolla, CA 92037 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2008年 / 8卷 / 05期

关键词：

D O I：

10.1038/nri2303

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies have revealed that the TAM receptor protein tyrosine kinases - TYRO3, AXL and MER - have pivotal roles in innate immunity. They inhibit inflammation in dendritic cells and macrophages, promote the phagocytosis of apoptotic cells and membranous organelles, and stimulate the maturation of natural killer cells. Each of these phenomena may depend on a cooperative interaction between TAM receptor and cytokine receptor signalling systems. Although its importance was previously unrecognized, TAM signalling promises to have an increasingly prominent role in studies of innate immune regulation.

引用

页码：327 / 336

页数：10

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