Design, synthesis and biological evaluation of 1,3-diaminopropanes: A new class of polyamine analogs as leishmanicidal agents

被引：7

作者：

Kumar, V

Singh, SK

Sharma, S

Bhaduri, AP

Gupta, S

Zaidi, A

Tiwari, S

Katiyar, JC

机构：

[1] CENT DRUG RES INST,DEPT MED CHEM,LUCKNOW 226001,UTTAR PRADESH,INDIA

[2] CENT DRUG RES INST,DEPT PARASITOL,LUCKNOW 226001,UTTAR PRADESH,INDIA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(97)00087-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Analogs of I,S-diaminopropane as inhibitors for the growth of Leishmania donovani have been synthesized and evaluated,for their antileishmanial activity. Of the many active compounds, 1-(3-N,N-bis methoxycarbonyl guanidino)propyl-4-methylpiperidine piperazine (4e,f) exhibited significant in vivo inhibitory efficacy against L. donovani by oral and intraperitoneal route of administration. (C) 1997 Elsevier Science Ltd.

引用

页码：675 / 680

页数：6

共 8 条

[1] BACHRACH U, 1981, MED BIOL, V59, P441
[2] SUPPRESSION OF BOTH ANTIMONY-SUSCEPTIBLE AND ANTIMONY-RESISTANT LEISHMANIA-DONOVANI BY A BIS(BENZYL)POLYAMINE ANALOG
BAUMANN, RJ
HANSON, WL
MCCANN, PP
SJOERDSMA, A
BITONTI, AJ
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (05) : 722 - 727
[3] SUPPRESSION OF LEISHMANIA-DONOVANI BY ORAL-ADMINISTRATION OF A BIS(BENZYL)POLYAMINE ANALOG
BAUMANN, RJ
MCCANN, PP
BITONTI, AJ
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (07) : 1403 - 1407
[4] BHATNAGAR S, 1989, INDIAN J MED RES-A, V89, P439
[5] *CDRI, 5611 CDRI
[6] Kandpal M, 1996, LIFE SCI, V59, pPL75, DOI 10.1016/0024-3205(96)00341-4
[7] RAUFOS I, 1996, J MED CHEM, V39, P1514
[8] POLYAMINE SYNTHESIS AND LEVELS DURING THE GROWTH AND REPLICATION OF LEISHMANIA-TROPICA-MINOR AND LEISHMANIA-AETHIOPICA
SCHNUR, LF
BACHRACH, U
GREENBLATT, CL
JOSEPH, MB
[J]. FEBS LETTERS, 1979, 106 (01) : 202 - 206

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