The stability of intramolecular DNA quadruplexes with extended loops forming inter- and intra-loop duplexes

被引：24

作者：

Risitano, A ^{[1
]}

Fox, KR ^{[1
]}

机构：

[1] Univ Southampton, Div Biochem & Mol Biol, Sch Biol Sci, Southampton SO16 7PX, Hants, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2003年 / 1卷 / 11期

关键词：

D O I：

10.1039/b302251j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have examined the formation of intramolecular quadruplex DNA structures in which the loops have been extended so as to generate short DNA duplexes. Fluorescence melting and DNase I cleavage studies show that duplexes can be formed within each loop, but that duplexes between the loops are not stable.

引用

页码：1852 / 1855

页数：4

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