Heat shock proteins: Applications in health and disease

被引：43

作者：

Jindal, S

机构：

[1] PerSeptive Biosystems, Framingham, MA 01701

来源：

TRENDS IN BIOTECHNOLOGY | 1996年 / 14卷 / 01期

关键词：

D O I：

10.1016/0167-7799(96)80909-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Heat shock proteins (hsps) assist the assembly, folding and translocation of other proteins, and apparently have a role in protecting cells against injuries and other types of stress. In addition, hsps are frequently recognized by the immune system as predominant antigens during infections and during the progression of certain autoimmune diseases and, thus, might provide a novel route for the development of immunotherapeutics. This review focuses on applications for hsps in health and disease, and discusses the pros and cons of considering them as targets for the development of therapeutics/pharmaceuticals.

引用

页码：17 / 20

页数：4

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[1] AFFINITY PANNING OF A LIBRARY OF PEPTIDES DISPLAYED ON BACTERIOPHAGES REVEALS THE BINDING-SPECIFICITY OF BIP [J].