Triggering bilayer to inverted-hexagonal nanostructure formation by thiol-ene click chemistry on cationic lipids: consequences on gene transfection

被引：20

作者：

Afonso, Damien ^{[1
]}

Le Gall, Tony ^{[2
]}

Couthon-Gourves, Helene ^{[1
]}

Grelard, Axelle ^{[3
]}

Prakash, Shipra ^{[3
]}

Berchel, Mathieu ^{[1
]}

Kervarec, Nelly ^{[1
]}

Dufourc, Erick J. ^{[3
]}

Montier, Tristan ^{[2
,4
,5
]}

Jaffres, Paul-Alain ^{[1
]}

机构：

[1] Univ Brest, Plateforme RMN RPE MS, CEMCA CNRS UMR 6521, IBSAM, 6 Ave V Le Gorgeu, F-29238 Brest, France

[2] Univ Brest, IBSAM, Fac Med & Sci Sante, INSERM U1078, 22 Ave Camille Desmoulins, F-29238 Brest 3, France

[3] Univ Bordeaux, UMR CNRS 5248, Inst Chem & Biol Membranes & Nanoobjects, CBMN,Bordeaux INP, Allee Geoffroy de St Hilaire, F-33600 Pessac, France

[4] CHRU Brest, Hop Morvan, 5 Ave Marechal Foch, F-29609 Brest, France

[5] Fac Med & Sci Sante, DUMG, 22 Ave Camille Desmoulins, F-29238 Brest 3, France

来源：

SOFT MATTER | 2016年 / 12卷 / 20期

关键词：

LIPOSOME-DNA COMPLEXES; NUCLEIC-ACID DELIVERY; HIGHLY EFFICIENT; CHEMICAL VECTORS; DRUG-DELIVERY; IN-VITRO; PHASE; LIPOPHOSPHORAMIDATE; PHOSPHATIDYLETHANOLAMINE; POLYMORPHISM;

D O I：

10.1039/c6sm00609d

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

The ramification of cationic amphiphiles on their unsaturated lipid chains is readily achieved by using the thiol-ene click reaction triggering the formation of an inverted hexagonal phase (H-II). The new ramified cationic lipids exhibit different bio-activities (transfection, toxicity) including higher transfection efficacies on 16HBE 14o-cell lines.

引用

收藏

页码：4516 / 4520

页数：5

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共 50 条

[1]

Plant sterols in "rafts": a better way to regulate membrane thermal shocks [J].

Beck, Johannes G. ;

Mathieu, Damien ;

Loudet, Cecile ;

Buchoux, Sebastien ;

Dufourc, Erick J. .

FASEB JOURNAL, 2007, 21 (08) :1714-1723

[2]

Transfection mediated by gemini surfactants: Engineered escape from the endosomal compartment [J].

Bell, PC ;

Bergsma, M ;

Dolbnya, IP ;

Bras, W ;

Stuart, MCA ;

Rowan, AE ;

Feiters, MC ;

Engberts, JBFN .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (06) :1551-1558

[3]

Lipophosphoramidate-based bipolar amphiphiles: their syntheses and transfection properties [J].

Berchel, Mathieu ;

Le Gall, Tony ;

Lozach, Olivier ;

Haelters, Jean-Pierre ;

Montier, Tristan ;

Jaffres, Paul-Alain .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2016, 14 (10) :2846-2853

[4]

Lipophosphonate/lipophosphoramidates: A family of synthetic vectors efficient for gene delivery [J].

Berchel, Mathieu ;

Le Gall, Tony ;

Couthon-Gourves, Helene ;

Haelters, Jean-Pierre ;

Montier, Tristan ;

Midoux, Patrick ;

Lehn, Pierre ;

Jaffres, Paul-Alain .

BIOCHIMIE, 2012, 94 (01) :33-41

[5]

Gene transfer by chemical vectors, and endocytosis routes of polyplexes, lipoplexes and lipopolyplexes in a myoblast cell line [J].

Billiet, Ludivine ;

Gomez, Jean-Pierre ;

Berchel, Mathieu ;

Jaffres, Paul-Alain ;

Le Gall, Tony ;

Montier, Tristan ;

Bertrand, Emilie ;

Cheradame, Herve ;

Guegan, Philippe ;

Mevel, Mathieu ;

Pitard, Bruno ;

Benvegnu, Thierry ;

Lehn, Pierre ;

Pichon, Chantal ;

Midoux, Patrick .

BIOMATERIALS, 2012, 33 (10) :2980-2990

[6]

Boussif O, 1996, GENE THER, V3, P1074

[7]

Disulfide-containing parenteral delivery systems and their redox-biological fate [J].

Bruelisauer, Lorine ;

Gauthier, Marc A. ;

Leroux, Jean-Christophe .

JOURNAL OF CONTROLLED RELEASE, 2014, 195 :147-154

[8]

Bioreducible Liposomes for Gene Delivery: From the Formulation to the Mechanism of Action [J].

Candiani, Gabriele ;

Pezzoli, Daniele ;

Ciani, Laura ;

Chiesa, Roberto ;

Ristori, Sandra .

PLOS ONE, 2010, 5 (10)

[9]

Enhanced Achilles tendon healing by fibromodulin gene transfer [J].

Delalande, Anthony ;

Gosselin, Marie-Pierre ;

Suwalski, Arnaud ;

Guilmain, William ;

Leduc, Chloe ;

Berchel, Mathieu ;

Jaffres, Paul-Alain ;

Baril, Patrick ;

Midoux, Patrick ;

Pichon, Chantal .

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2015, 11 (07) :1735-1744

[10]

Synthetic Nucleic Acid Delivery Systems: Present and Perspectives [J].

Draghici, Bogdan ;

Ilies, Marc A. .

JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (10) :4091-4130

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