Effects of a chitosan membrane coated with polylactic and polyglycolic acid on bone regeneration in a rat calvarial defect

被引：24

作者：

Jung, Ui-Won

Song, Kun-Young

Kim, Chang-Sung

Lee, Yong-Keun

Cho, Kyoo-Sung

Kim, Chong-Kwan

Choi, Seong-Ho

机构：

[1] Yonsei Univ, Coll Dent, Dept Perinatol, Res Inst Periodontal Regenerat, Seoul 1207521, South Korea

[2] Yonsei Univ, Coll Dent, Dept & Res Inst Dent Biomat & Bioengn, Seoul 1207521, South Korea

来源：

BIOMEDICAL MATERIALS | 2007年 / 2卷 / 03期

关键词：

GUIDED TISSUE REGENERATION; FREEZE-DRIED BONE; INTRABONY DEFECTS; PERIODONTAL REPAIR; CALCIUM-SULFATE; ALVEOLAR BONE; DOGS; IMPLANTS;

D O I：

10.1088/1748-6041/2/3/S03

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

The purpose of this study was to evaluate the effects of a chitosan membrane coated with polylactic and polyglycolic acid ( PLGA) on bone regeneration in a rat calvarial defect. Surgical implantation of chitosan membranes resulted in enhanced local bone formation at both 2 and 8 weeks. In conclusion, the chitosan membrane coated with PLGA had a significant potential to induce bone formation in the rat calvarial defect model. Within the selected PLGA dose range and observation intervals, there appeared to be no meaningful differences in bone formation.

引用

页码：S101 / S105

页数：5

共 22 条

[1]

A COMPARISON OF EPTFE MEMBRANES ALONE OR IN COMBINATION WITH PLATELET-DERIVED GROWTH-FACTORS AND INSULIN-LIKE GROWTH FACTOR-I OR DEMINERALIZED FREEZE-DRIED BONE IN PROMOTING BONE-FORMATION AROUND IMMEDIATE EXTRACTION SOCKET IMPLANTS [J].