Three-dimensional modeling of biopsy protocols for localized prostate cancer

被引：20

作者：

Loughlin, M ^{[1
]}

Carlbom, I ^{[1
]}

Busch, C ^{[1
]}

Douglas, T ^{[1
]}

Egevad, L ^{[1
]}

Frimmel, H ^{[1
]}

Norberg, M ^{[1
]}

Sesterhenn, I ^{[1
]}

Frogge, JM ^{[1
]}

机构：

[1] FutureTense Inc, Acton, MA 01720 USA

来源：

COMPUTERIZED MEDICAL IMAGING AND GRAPHICS | 1998年 / 22卷 / 03期

关键词：

biopsy protocol; prostate cancer; three-dimensional modeling; needle core biopsy; biopsy simulation; registration; reconstruction; volume rendering;

D O I：

10.1016/S0895-6111(98)00019-6

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Prostate cancer is the most common malignant tumor in American men, yet only a small percentage of men will develop clinically significant disease. Needle core biopsies are used to confirm the presence of cancer prior to surgery. While needle core biopsies have shown some ability to predict tumor volume and grade in prostatectomy specimens, for the individual patient they are neither sensitive nor specific enough to guide therapy. In this paper, we describe a system for simulating needle biopsies on three-dimensional models of cancerous prostates reconstructed from serial sections. First we segment the serial sections,delineating tumors and landmarks. Next, we register the sections using a color-merging scheme, and reconstruct the three-dimensional model using modified-shape-based interpolation. The resulting volume can be rendered, and simulated needle core biopsies can be taken from the reconstructed model. We use our system to simulate two different biopsy protocols on a reconstructed prostate specimen. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：229 / 238

页数：10

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