Asymmetrical modulation of interleukin-10 release in patients with intracerebral hemorrhage

被引：18

作者：

Dziedzic, T ^{[1
]}

Slowik, A ^{[1
]}

Klimkowicz, A ^{[1
]}

Szczudlik, A ^{[1
]}

机构：

[1] Jagiellonian Univ, Coll Med, Dept Neurol, PL-31503 Krakow, Poland

来源：

BRAIN BEHAVIOR AND IMMUNITY | 2003年 / 17卷 / 06期

关键词：

interleukin-6; interleukin-10; cytokines; intracerebral hemorrhage; brain asymmetry; immunomodulation;

D O I：

10.1016/S0889-1591(03)00064-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

The brain modulates the immune system in an asymmetrical way. Intracerebral hemorrhage triggers IL-6 and IL-10 release into blood. We measured (using ELISA method) serum IL-6 and IL-10 in acute phase of intracerebral hemorrhage in 11 patients with right hemisphere's hematoma and 15 patients with left hemisphere's hematoma. These patients did not differ significantly with respect to their age, size, and location of hematoma. IL-6 level was comparable in patients with left hematoma and patients with right hematoma, but patients with left hematoma had significantly higher level of IL-10 than patients with right hematoma. These results suggest that left and right hemisphere could modulate IL-10 release in different way. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：438 / 441

页数：4

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