Comparison of bone resorption markers during hypocalcemia in dairy cows

被引:61
作者
Liesegang, A
Sassi, ML
Risteli, J
Eicher, R
Wanner, M
Riond, JL
机构
[1] Univ Zurich, Inst Anim Nutr, CH-8057 Zurich, Switzerland
[2] Univ Oulu, Dept Biochem Med, FIN-90220 Oulu, Finland
[3] Univ Oulu, Dept Clin Chem, FIN-90220 Oulu, Finland
[4] Univ Bern, Clin Food Anim & Horses, CH-3012 Bern, Switzerland
基金
英国医学研究理事会;
关键词
hypocalcemia; cow; bone resorption; milk fever;
D O I
10.3168/jds.S0022-0302(98)75819-9
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
This study investigated whether hydroxyproline, deoxypyridinoline, or the carboxyterminal telopeptide of type I collagen could be used as markers to provide evidence of bone resorption during hypocalcemia of dairy cows. Serum concentrations of the aminoterminal propeptide of type III procollagen were also analyzed to study the effect; of parturition on type III collagen, which is a component of soft connective tissues. Urine and blood samples were collected on d 1 to 5, on d 9, and d 14 after parturition from 18 cows with symptoms of periparturient paresis (:group 1) and 19 healthy control cows without symptoms (group 2), Urine concentrations of hydroxyproline and deoxypyridinoline were measured with a colorimetric assay and an enzyme immunoassay, respectively. Serum concentrations of the amino-terminal propeptide of type III procollagen were measured using a commercially available radioimmunoassay. A radioimmunoassay was developed to analyze serum concentrations of the carboxyterminal telopeptide of bovine type I collagen. The mean corrected urinary hydroxyproline concentrations in group 1 increased from parturition to d 14; concentrations in group I were significantly higher for group 2 after d 5. Mean corrected deoxypyridinoline concentrations in urine increased after parturition to reach a peak at d 9, and serum concentrations of the carboxyterminal telopeptide of type I collagen peaked at d 5. However, mean concentrations of deoxypyridinoline and the carboxyterminal telopeptide of type I collagen did not differ significantly between groups. The variation in the behavior of the three markers is likely a reflection of the different phases and aspects of the bone collagen degradation. In conclusion, assays for urinary deoxypyridinoline and serum carboxyterminal telopeptide of type I collagen determinations are useful tools to follow the course of degradation of bone collagen in dairy cows.
引用
收藏
页码:2614 / 2622
页数:9
相关论文
共 50 条
[1]   MILK FEVER AND CALCIUM-METABOLISM [J].
ALLEN, WM ;
SANSOM, BF .
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 1985, 8 (01) :19-29
[2]   DISEASE FREQUENCIES IN DAIRY-COWS IN SWEDEN .3. PARTURIENT PARESIS [J].
BENDIXEN, PH ;
VILSON, B ;
EKESBO, I ;
ASTRAND, DB .
PREVENTIVE VETERINARY MEDICINE, 1987, 5 (02) :87-97
[3]   2 IMPROVED AND SIMPLIFIED METHODS FOR SPECTROPHOTOMETRIC DETERMINATION OF HYDROXYPROLINE [J].
BERGMAN, I ;
LOXLEY, R .
ANALYTICAL CHEMISTRY, 1963, 35 (12) :1961-&
[4]   QUANTITATIVE-ANALYSIS OF THE PYRIDINIUM CROSSLINKS OF COLLAGEN IN URINE USING ION-PAIRED REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].
BLACK, D ;
DUNCAN, A ;
ROBINS, SP .
ANALYTICAL BIOCHEMISTRY, 1988, 169 (01) :197-203
[5]   Noninvasive markers of bone metabolism in the rhesus monkey: Normal effects of age and gender [J].
Cahoon, S ;
Boden, SD ;
Gould, KG ;
Vailas, AC .
JOURNAL OF MEDICAL PRIMATOLOGY, 1996, 25 (05) :333-338
[6]   ASSESSMENT OF BONE REMODELING USING BIOCHEMICAL INDICATORS OF TYPE-I COLLAGEN-SYNTHESIS AND DEGRADATION - RELATION TO CALCIUM KINETICS [J].
CHARLES, P ;
MOSEKILDE, L ;
RISTELI, L ;
RISTELI, J ;
ERIKSEN, EF .
BONE AND MINERAL, 1994, 24 (02) :81-94
[7]  
Colwell A, 1996, J BONE MINER RES, V11, P1976
[8]  
Cosman F, 1996, CALCIFIED TISSUE INT, V58, P236
[9]  
DYRENDAHL I, 1972, ZENTRALB VET RIEHE A, V19, P621
[10]  
EGGER CD, 1994, J BONE MINER RES, V9, P1211