Biodegradable Nanoparticles Composed Entirely of Safe Materials that Rapidly Penetrate Human Mucus

被引：217

作者：

Yang, Ming ^{[6
]}

Lai, Samuel K.

Wang, Ying-Ying ^{[6
]}

Zhong, Weixi ^{[6
]}

Happe, Christina

Zhang, Michael

Fu, Jie

Hanes, Justin ^{[1
,2
,3
,4
,5
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Ophthalmol, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Baltimore, MD 21287 USA

[3] Johns Hopkins Univ, Sch Med, Dept Chem & Biomol Engn, Baltimore, MD 21287 USA

[4] Johns Hopkins Univ, Sch Med, Dept Oncol, Ctr Canc Nanotechnol Excellence,Inst NanoBioTechn, Baltimore, MD 21287 USA

[5] Johns Hopkins Univ, Sch Med, Ctr Nanomed, Baltimore, MD 21287 USA

[6] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21287 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 11期

基金：

美国国家科学基金会;

关键词：

drug delivery; GRAS (generally recognized as safe); mucus-penetrating particles; nanotechnology; Pluronics; GENE DELIVERY; DRUG; PARTICLES; TRANSPORT; EVOLUTION; THERAPY; SYSTEMS;

D O I：

10.1002/anie.201006849

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Slipping through: Pluronic molecules adsorb onto nanoparticle surfaces through their polypropylene oxide (PPO) segments with the flanking polyethylene glycol (PEG) segments forming a dense muco-inert brush (see picture; top). While uncoated particles are immobilized in mucus through adhesive interactions with mucus mesh elements, coated particles diffuse rapidly through spaces in the mucus mesh (bottom). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2597 / 2600

页数：4

共 26 条

[1] Pluronic block copolymers: Evolution of drug delivery concept from inert nanocarriers to biological response modifiers [J].

Batrakova, Elena V. ;

Kabanov, Alexander V. .

JOURNAL OF CONTROLLED RELEASE, 2008, 130 (02) :98-106

[2] Barrier properties of mucus [J].

Cone, Richard A. .

ADVANCED DRUG DELIVERY REVIEWS, 2009, 61 (02) :75-85

[3] Enhanced viscoelasticity of human cystic fibrotic sputum correlates with increasing microheterogeneity in particle transport [J].

Dawson, M ;

Wirtz, D ;

Hanes, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (50) :50393-50401

[4] A placebo-controlled multi-centred evaluation of an anaesthetic gel (Oraqix®) for periodontal therapy [J].

Donaldson, D ;

Gelskey, SC ;

Landry, RG ;

Matthews, DC ;

Sandhu, HS .

JOURNAL OF CLINICAL PERIODONTOLOGY, 2003, 30 (03) :171-175

[5] A review of poloxamer 407 pharmaceutical and pharmacological characteristics [J].

Dumortier, Gilles ;

Grossiord, Jean Louis ;

Agnely, Florence ;

Chaumeil, Jean Claude .

PHARMACEUTICAL RESEARCH, 2006, 23 (12) :2709-2728

[6]

Emanuele R M, 1998, Expert Opin Investig Drugs, V7, P1193, DOI 10.1517/13543784.7.7.1193

[7]

Escobar-Chávez JJ, 2006, J PHARM PHARM SCI, V9, P339

[8] New polymeric carriers for controlled drug delivery following inhalation or injection [J].

Fu, J ;

Fiegel, J ;

Krauland, E ;

Hanes, J .

BIOMATERIALS, 2002, 23 (22) :4425-4433

[9] The origins and evolution of "controlled" drug delivery systems [J].

Hoffman, Allan S. .

JOURNAL OF CONTROLLED RELEASE, 2008, 132 (03) :153-163

[10] THE ORGAN UPTAKE OF INTRAVENOUSLY ADMINISTERED COLLOIDAL PARTICLES CAN BE ALTERED USING A NON-IONIC SURFACTANT (POLOXAMER-338) [J].

ILLUM, L ;

DAVIS, SS .

FEBS LETTERS, 1984, 167 (01) :79-82

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